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    GAMMA-TIP gamma tonoplast intrinsic protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818255, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAMMA-TIP
    Official Full Name
    gamma tonoplast intrinsic protein
    Primary source
    TAIR:AT2G36830
    Locus tag
    AT2G36830
    See related
    Araport:AT2G36830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    gamma tonoplast intrinsic protein; GAMMA TONOPLAST INTRINSIC PROTEIN 1; GAMMA-TIP1; GAMMA-TONOPLAST INTRINSIC PROTEIN; T1J8.1; T1J8_1; TIP1;1; TONOPLAST INTRINSIC PROTEIN 1;1
    Summary
    Encodes a tonoplast intrinsic protein, which functions as water channel. It has also been shown to be able to facilitate the transport of urea and hydrogen peroxide. Highly expressed in vascular tissues of the root, stem, cauline leaves and flowers but not in the apical meristems.
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    Genomic context

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    See GAMMA-TIP in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (15445294..15446621)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene mid region of cactin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ACT-like superfamily protein Neighboring gene glucan synthase-like 8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The vacuolar membrane protein gamma-TIP creates water specific channels in Xenopus oocytes. Maurel C, et al. EMBO J, 1993 Jun. PMID 8508761, Free PMC Article
    2. A complex and mobile structure forms a distinct subregion within the continuous vacuolar membrane in young cotyledons of Arabidopsis. Saito C, et al. Plant J, 2002 Feb. PMID 11844103
    3. Life with and without AtTIP1;1, an Arabidopsis aquaporin preferentially localized in the apposing tonoplasts of adjacent vacuoles. Beebo A, et al. Plant Mol Biol, 2009 May. PMID 19229639
    4. The effects of the loss of TIP1;1 and TIP1;2 aquaporins in Arabidopsis thaliana. Schüssler MD, et al. Plant J, 2008 Dec. PMID 18643996
    5. Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. Bienert GP, et al. J Biol Chem, 2007 Jan 12. PMID 17105724

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the highly abundant tonoplast aquaporins (AQPs) isoforms AtTIP1;1, AtTIP1;2, and AtTIP2;1 facilitate the emergence of new lateral root primordia (LRPs).
      Title: Tonoplast Aquaporins Facilitate Lateral Root Emergence.
    2. TIP1;1 and TIP1;2 single or double mutants did not show significant changes in water content or water retention, and showed no sign of early senescence or growth retardation. [TIP1;1]
      Title: The effects of the loss of TIP1;1 and TIP1;2 aquaporins in Arabidopsis thaliana.
    3. unlike for TIP1;1, trafficking of markers for TIP3;1 and TIP2;1 is insensitive to Brefeldin A in Arabidopsis hypocotyls
      Title: A small molecule inhibitor partitions two distinct pathways for trafficking of tonoplast intrinsic proteins in Arabidopsis.
    4. AtTIP1;1 is present in multiple vacuolar compartments and is preferentially found in the apposing tonoplasts of adjacent vacuoles. AtTIP1;1 loss of function did not lead to early plant death.
      Title: Life with and without AtTIP1;1, an Arabidopsis aquaporin preferentially localized in the apposing tonoplasts of adjacent vacuoles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_129238.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables urea transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gibberellic acid mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within hydrogen peroxide transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within urea transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in central vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in protein storage vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma tonoplast intrinsic protein
    NP_181221.1
    • gamma tonoplast intrinsic protein (GAMMA-TIP); FUNCTIONS IN: water channel activity, urea transmembrane transporter activity; INVOLVED IN: in 6 processes; LOCATED IN: in 7 components; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: tonoplast intrinsic protein 2 (TAIR:AT3G26520.1); Has 11016 Blast hits to 10983 proteins in 2213 species: Archae - 82; Bacteria - 5238; Metazoa - 1501; Fungi - 451; Plants - 2489; Viruses - 0; Other Eukaryotes - 1255 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15445294..15446621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129238.4 → NP_181221.1  gamma tonoplast intrinsic protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181221.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21652, P25818, Q42075, Q8L5T8
      UniProtKB/TrEMBL
      A0A5S9X4N0, A0A654FA46
      Conserved Domains (1) summary
      PLN00027
      Location:1 → 251
      PLN00027; aquaporin TIP; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25818.1

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