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    PP2C5 phosphatase 2C5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818609, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PP2C5
    Official Full Name
    phosphatase 2C5
    Primary source
    TAIR:AT2G40180
    Locus tag
    AT2G40180
    See related
    Araport:AT2G40180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHPP2C5; phosphatase 2C5; T7M7.17
    Summary
    Encodes PP2C5, a member of the PP2C family phosphatases. PP2C5 acts as a MAPK phosphatase that positively regulates seed germination, stomatal closure and ABA-inducible gene expression.
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    Genomic context

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    See PP2C5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (16782366..16784147)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene Stress induced protein Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Ribosomal protein L41 family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. Umbrasaite J, et al. PLoS One, 2010 Dec 23. PMID 21203456, Free PMC Article
    2. Bimolecular fluorescent complementation (BiFC) by MAP kinases and MAPK phosphatases. Schweighofer A, et al. Methods Mol Biol, 2014. PMID 24908126
    3. The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression. Brock AK, et al. Plant Physiol, 2010 Jul. PMID 20488890, Free PMC Article
    4. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PP2C5 acts as a mitogen-activated protein kinases phosphatase that positively regulates seed germination, stomatal closure, and ABA-inducible gene expression. [PP2C5]
      Title: The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129576.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal lineage progression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatase 2C5
    NP_181547.1
    • phosphatase 2C5 (PP2C5); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT1G07160.1); Has 6862 Blast hits to 6800 proteins in 519 species: Archae - 10; Bacteria - 469; Metazoa - 1632; Fungi - 782; Plants - 2690; Viruses - 9; Other Eukaryotes - 1270 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16782366..16784147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129576.3 → NP_181547.1  phosphatase 2C5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84K48, Q9XEE8
      UniProtKB/TrEMBL
      A0A178VQY5, A0A5S9X5N9, A0A654F1T1, F6LPR7
      Conserved Domains (1) summary
      cd00143
      Location:128 → 385
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XEE8.1

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