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    RPM1 NB-ARC domain-containing disease resistance protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819889, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPM1
    Official Full Name
    NB-ARC domain-containing disease resistance protein
    Primary source
    TAIR:AT3G07040
    Locus tag
    AT3G07040
    See related
    Araport:AT3G07040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DISEASE RESISTANCE PROTEIN RPM1; RESISTANCE TO P. SYRINGAE PV MACULICOLA 1; RESISTANCE TO PSEUDOMONAS SYRINGAE 3; RPS3
    Summary
    Contains an N-terminal tripartite nucleotide binding site and a C-terminal tandem array of leucine-rich repeats. Confers resistance to Pseudomonas syringae strains that carry the avirulence genes avrB and avrRpm1.
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    Genomic context

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    See RPM1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (2225855..2229555, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene Alba DNA/RNA-binding protein Neighboring gene GTP-binding family protein Neighboring gene tRNA-Met Neighboring gene NHL domain-containing protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The analogous and opposing roles of double-stranded RNA-binding proteins in bacterial resistance. Lim GH, et al. J Exp Bot, 2019 Mar 11. PMID 30843586
    2. Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance. Grant MR, et al. Science, 1995 Aug 11. PMID 7638602
    3. Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death. Gopalan S, et al. Plant Cell, 1996 Jul. PMID 8768370, Free PMC Article
    4. The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response. Boyes DC, et al. Proc Natl Acad Sci U S A, 1998 Dec 22. PMID 9861059, Free PMC Article
    5. Plant intracellular innate immune receptor Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) is activated at, and functions on, the plasma membrane. Gao Z, et al. Proc Natl Acad Sci U S A, 2011 May 3. PMID 21490299, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis.
      Title: Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis.
    2. Degradation of RPM1 is not associated with HR or resistance mediated by this R protein. Likewise, the runaway cell death phenotype in the lsd1 mutant was not associated with RPM1 degradation and did not alter RPM1-derived resistance. RPM1 stability and RPM1-mediated resistance were dependent on the double-stranded RNA binding (DRB) proteins 1 and 4.
      Title: The analogous and opposing roles of double-stranded RNA-binding proteins in bacterial resistance.
    3. RPM1, RPS2 and RPS5 are R proteins. Here, we provide evidence that FLS2 is physically associated with all three R proteins.
      Title: Physical association of pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) immune receptors in Arabidopsis.
    4. RPM1 is activated at, and functions on, the plasma membrane.
      Title: Plant intracellular innate immune receptor Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) is activated at, and functions on, the plasma membrane.
    5. RIPK (At2g05940) phosphorylates the host target RIN4, leading to the activation of RPM1 during Pseudomonas syringae infection.
      Title: A receptor-like cytoplasmic kinase phosphorylates the host target RIN4, leading to the activation of a plant innate immune receptor.
    6. Threonine phosphorylation of Arabidopsis RIN4 by Pseudomonas AvrRpm1 and AvrB activates Arabidopsis immune receptor RPM1.
      Title: Specific threonine phosphorylation of a host target by two unrelated type III effectors activates a host innate immune receptor in plants.
    7. Data show that a PP2C-type phosphatase (renamed PIA1) was identified that accumulates following infection by Pseudomonas syringae expressing AvrRpm1 and subsequent activation of the corresponding plant NB-LRR disease resistance protein RPM1.
      Title: A protein phosphatase 2C, responsive to the bacterial effector AvrRpm1 but not to the AvrB effector, regulates defense responses in Arabidopsis.
    8. Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
      Title: A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.
    9. AvrB is activated inside the host cell by nucleotide binding and subsequent phosphorylation and interacts with RIN4. Aactivated AvrB, bound to RIN4, is indirectly recognized by RPM1 to initiate plant immune system function.
      Title: Type III effector activation via nucleotide binding, phosphorylation, and host target interaction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111584.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NB-ARC domain-containing disease resistance protein
    NP_187360.1
    • RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1); FUNCTIONS IN: protein binding, nucleotide binding; INVOLVED IN: defense response, plant-type hypersensitive response; LOCATED IN: plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT5G35450.1); Has 20241 Blast hits to 16785 proteins in 626 species: Archae - 16; Bacteria - 1308; Metazoa - 4084; Fungi - 259; Plants - 14046; Viruses - 4; Other Eukaryotes - 524 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2225855..2229555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111584.3 → NP_187360.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187360.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39214
      UniProtKB/TrEMBL
      A0A7G2EJ37
      Conserved Domains (6) summary
      cd01983
      Location:195 → 213
      Fer4_NifH; The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.
      cd14798
      Location:2 → 130
      RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
      sd00033
      Location:583 → 605
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:175 → 467
      NB-ARC; NB-ARC domain
      pfam12799
      Location:605 → 643
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:583 → 639
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39214.1

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