AOX1A alternative oxidase 1A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AOX1A
Official Full Name: alternative oxidase 1A
Primary source: TAIR:AT3G22370
Locus tag: AT3G22370
See related: Araport:AT3G22370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: alternative oxidase 1A; ATAOX1A; AtHSR3; HSR3; hyper-sensitivity-related 3
Summary: Encodes AOX1a, an isoform of alternative oxidase that is expressed in rosettes, flowers, and root. The alternative oxidase of plant mitochondria transfers electrons from the ubiquinone pool to oxygen without energy conservations. It is regulated through transcriptional control and by pyruvate. Plays a role in shoot acclimation to low temperature. Also is capable of ameliorating reactive oxygen species production when the cytochrome pathway is inhibited. AOX1a also functions as a marker for mitochondrial retrograde response.
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Genomic context

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See AOX1A in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (7906521..7908746)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Responses of genes of DNA repair, alternative oxidase, and pro-/antioxidant state in Arabidopsis thaliana with altered expression of AOX1a to gamma irradiation.
Title: Responses of genes of DNA repair, alternative oxidase, and pro-/antioxidant state in Arabidopsis thaliana with altered expression of AOX1a to gamma irradiation.
UCP1 and AOX1a contribute to regulation of carbon and nitrogen metabolism and yield in Arabidopsis under low nitrogen stress.
Title: UCP1 and AOX1a contribute to regulation of carbon and nitrogen metabolism and yield in Arabidopsis under low nitrogen stress.
The gene expression profiles of mitochondrial respiratory components in Arabidopsis plants with differing amounts of ALTERNATIVE OXIDASE1a under high intensity light.
Title: The gene expression profiles of mitochondrial respiratory components in Arabidopsis plants with differing amounts of ALTERNATIVE OXIDASE1a under high intensity light.
Retrograde signals from mitochondria reprogramme skoto-morphogenesis in Arabidopsis thaliana via alternative oxidase 1a.
Title: Retrograde signals from mitochondria reprogramme skoto-morphogenesis in Arabidopsis thaliana via alternative oxidase 1a.
SUMOylation of MYB30 enhances salt tolerance by elevating alternative respiration via transcriptionally upregulating AOX1a in Arabidopsis.
Title: SUMOylation of MYB30 enhances salt tolerance by elevating alternative respiration via transcriptionally upregulating AOX1a in Arabidopsis.
AtNDB2 Is the Main External NADH Dehydrogenase in Mitochondria and Is Important for Tolerance to Environmental Stress.
Title: AtNDB2 Is the Main External NADH Dehydrogenase in Mitochondria and Is Important for Tolerance to Environmental Stress.
The results highlight the importance of alternative oxidase (AOX) in plant response to UVB for the control of a balanced metabolism, and indicate that AOX1a plays a key role in the regulation of the stress response.
Title: Altered levels of AOX1a expression result in changes in metabolic pathways in Arabidopsis thaliana plants acclimated to low dose rates of ultraviolet B radiation.
Similar to the expression of AOX1a the expression of AOX1d was also significantly elevated due to Pseudomonas syringae harpin protein treatment. Similar to the expression and activity of AOX, the transcript level of UCP4, UCP5 and the UCP activity increased due to Pseudomonas syringae harpin protein treatment and the consequential oxidative burst.
Title: Comparison of the response of alternative oxidase and uncoupling proteins to bacterial elicitor induced oxidative burst.
AOX1A activation by Tricarboxylic acid cycle Intermediates 2-oxoglutarate and oxaloacetate.
Title: Alternative Oxidase Isoforms Are Differentially Activated by Tricarboxylic Acid Cycle Intermediates.
AOX isoforms are differentially activated and that activation at CysI and CysII is additive.
Title: Analysis of Posttranslational Activation of Alternative Oxidase Isoforms.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_113135.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables alternative oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alternative oxidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables alternative oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables superoxide-generating NADPH oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquinol:oxygen oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular respiration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitochondria-nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: alternative oxidase 1A

NP_188876.1

alternative oxidase 1A (AOX1A); FUNCTIONS IN: alternative oxidase activity; INVOLVED IN: oxidation reduction, cellular respiration, response to cold, response to stress, mitochondria-nucleus signaling pathway; LOCATED IN: mitochondrion; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Alternative oxidase (InterPro:IPR002680); BEST Arabidopsis thaliana protein match is: alternative oxidase 1B (TAIR:AT3G22360.1); Has 1299 Blast hits to 1299 proteins in 245 species: Archae - 0; Bacteria - 109; Metazoa - 12; Fungi - 194; Plants - 380; Viruses - 0; Other Eukaryotes - 604 (source: NCBI BLink).