RGS1 REGULATOR OF G-PROTEIN SIGNALING 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RGS1
Official Full Name: REGULATOR OF G-PROTEIN SIGNALING 1
Primary source: TAIR:AT3G26090
Locus tag: AT3G26090
See related: Araport:AT3G26090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRGS1; REGULATOR OF G-PROTEIN SIGNALING 1
Summary: Encodes AtRGS1, a putative membrane receptor for D-glucose. Also functions as a regulator of G-protein signaling. Has GTPase-accelerating activity. Regulates the activity of AtGPA1. Lines over-expressing the gene are more tolerant to dehydration and root elongation. These phenotypes are dependent on ABA. Nuclear localization of the protein is dependent on ABA.
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Genomic context

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See RGS1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (9532613..9535629)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation Dynamics in a flg22-Induced, G Protein-Dependent Network Reveals the AtRGS1 Phosphatase.
Title: Phosphorylation Dynamics in a flg22-Induced, G Protein-Dependent Network Reveals the AtRGS1 Phosphatase.
Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
Title: Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1.
Title: Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1.
Reported differences in the flg22 response of the null mutation of AtRGS1 correlates with fixed genetic variation in the background of Col-0 isolates.
Title: Reported differences in the flg22 response of the null mutation of AtRGS1 correlates with fixed genetic variation in the background of Col-0 isolates.
This paper introduces relationship between autophagy and RGS1.
Title: Glucose signaling, AtRGS1 and plant autophagy.
RGS1 promoted production of autophagosomes and autophagic flux via interaction with ATG8a.
Title: Correlation of Autophagosome Formation with Degradation and Endocytosis Arabidopsis Regulator of G-Protein Signaling (RGS1) through ATG8a.
Jasmonic Acid signal activates heterotrimeric G proteins through the endocytosis of RGS1 and dissociation of RGS1 from GPA1, thus providing valuable insight into the mechanisms of how the G protein system perceives and transduces phytohormone signals.
Title: JA-Induced Endocytosis of AtRGS1 Is Involved in G-Protein Mediated JA Responses.
BRL3 and AtRGS1 are part of a fine-tuning mechanism sensing glucose and flg22 to prevent excess ROS burst and control growth inhibition
Title: BRL3 and AtRGS1 cooperate to fine tune growth inhibition and ROS activation.
complete contrast to G protein activation in animals, plant leucine-rich repeat receptor-like kinases (LRR RLKs), not GPCRs, provide this discrimination through phosphorylation of AtRGS1 in a ligand-dependent manner.
Title: Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex.
It was shown that endocytosis of RGS1 by ligand-dependent endocytosis physically uncouples the GTPase-accelerating activity of RGS1 from the Galpha protein, permitting sustained activation.
Title: Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001338780.1

Supported by ESTs:

NM_113514.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sugar mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: REGULATOR OF G-PROTEIN SIGNALING 1

NP_189238.2

REGULATOR OF G-PROTEIN SIGNALING 1 (RGS1); FUNCTIONS IN: G-protein coupled receptor activity, GTPase activator activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Regulator of G protein signalling superfamily (InterPro:IPR016137), Regulator of G protein signalling (InterPro:IPR000342); Has 59 Blast hits to 59 proteins in 16 species: Archae - 0; Bacteria - 0; Metazoa - 9; Fungi - 0; Plants - 16; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9532613..9535629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113514.4 → NP_189238.2 REGULATOR OF G-PROTEIN SIGNALING 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189238.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8H1F2, Q8RWS5, Q9LU81, Q9LU82

UniProtKB/TrEMBL

A0A5S9XFT3, A0A654FC37

Conserved Domains (1) summary

cd08732
Location:292 → 418

RGS-like_4; Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 4
NM_001338780.1 → NP_001327634.1 REGULATOR OF G-PROTEIN SIGNALING 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LSX6, A0A5S9XFT3, A0A654FC37