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    SUVR1 histone-lysine N-methyltransferase SUVR2-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839320, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUVR1
    Official Full Name
    histone-lysine N-methyltransferase SUVR2-like protein
    Primary source
    TAIR:AT1G04050
    Locus tag
    AT1G04050
    See related
    Araport:AT1G04050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT1G04060; F21M11.35; F21M11_35; homolog of SU(var)3-9 1; SDG13; SET DOMAIN PROTEIN 13
    Summary
    Encodes SUVR1, one of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, SUVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain. Localized to the nucleolus, maybe involved in regulation of rRNA expression.
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    Genomic context

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    See SUVR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (1045598..1049864, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene eisosome protein Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene ncRNA Neighboring gene translocase of outer membrane 22-I Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9. Thorstensen T, et al. Nucleic Acids Res, 2006. PMID 17020925, Free PMC Article
    2. The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Rahman MA, et al. Biochemistry, 2014 Apr 8. PMID 24625295, Free PMC Article
    3. SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis. Han YF, et al. Cell Res, 2014 Dec. PMID 25420628, Free PMC Article
    4. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001331459.1
    NM_100286.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SUVR2-like protein
    NP_171901.3
    • homolog of SU(var)3-9 1 (SUVR1); FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SET-domain containing protein lysine methyltransferase family protein (TAIR:AT5G43990.4); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1045598..1049864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331458.1 → NP_001320725.1  histone-lysine N-methyltransferase SUVR2-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64498, Q946J2, Q9SAW1
      UniProtKB/TrEMBL
      A0A178WJU9, A0A654E6K6
      Conserved Domains (2) summary
      cd10538
      Location:433 → 696
      SET_SETDB-like; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    2. NM_100286.4 → NP_171901.3  histone-lysine N-methyltransferase SUVR2-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171901.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64498, Q946J2, Q9SAW1
      UniProtKB/TrEMBL
      A0A178WJU9, A0A654E6K6
      Conserved Domains (2) summary
      cd10538
      Location:433 → 696
      SET_SETDB-like; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins
      pfam10440
      Location:6 → 59
      WIYLD; Ubiquitin-binding WIYLD domain

    3. NM_001331459.1 → NP_001320724.1  histone-lysine N-methyltransferase SUVR2-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ANQ7, A0A5S9SIE8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q946J2.2

    Gene LinkOut

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