U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LOX2 lipoxygenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823650, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LOX2
    Official Full Name
    lipoxygenase 2
    Primary source
    TAIR:AT3G45140
    Locus tag
    AT3G45140
    See related
    Araport:AT3G45140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIODOPSIS THALIANA LIPOXYGENASE 2; ATLOX2; lipoxygenase 2
    Summary
    Chloroplast lipoxygenase required for wound-induced jasmonic acid accumulation in Arabidopsis.Mutants are resistant to Staphylococcus aureus and accumulate salicylic acid upon infection.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (16525245..16529352)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TCP domain protein 16 Neighboring gene Putative membrane lipoprotein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser(600) inhibits enzyme activity. Kaur D, et al. J Biol Chem, 2023 Mar. PMID 36639029, Free PMC Article
    2. A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Bell E, et al. Proc Natl Acad Sci U S A, 1995 Sep 12. PMID 7567995, Free PMC Article
    3. Characterization of an Arabidopsis lipoxygenase gene responsive to methyl jasmonate and wounding. Bell E, et al. Plant Physiol, 1993 Dec. PMID 8290626, Free PMC Article
    4. Caterpillar saliva interferes with induced Arabidopsis thaliana defence responses via the systemic acquired resistance pathway. Weech MH, et al. J Exp Bot, 2008. PMID 18487634, Free PMC Article
    5. Arabidopsis lipoxygenase 2 is essential for formation of green leaf volatiles and five-carbon volatiles. Mochizuki S, et al. FEBS Lett, 2016 Apr. PMID 26991128

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.
      Title: Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.
    2. Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser[600] inhibits enzyme activity.
      Title: Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser(600) inhibits enzyme activity.
    3. Arabidopsis TCX8 functions as a senescence modulator by regulating LOX2 expression.
      Title: Arabidopsis TCX8 functions as a senescence modulator by regulating LOX2 expression.
    4. Ca2+-dependent activation of AtLOX2 facilitates green leaf volatile-burst formation
      Title: Green leaf volatile-burst in Arabidopsis is governed by galactolipid oxygenation by a lipoxygenase that is under control of calcium ion.
    5. Data (including data from genetically modified plants) suggest that LOX2 activity is suppressed in intact cells but activated upon tissue damage to support rapid green leaf volatile-burst observed in wounded leaves.
      Title: Arabidopsis lipoxygenase 2 is essential for formation of green leaf volatiles and five-carbon volatiles.
    6. In conditions of red light-induced defence, Arabidopsis LOX activity and transcription levels of LOX2, LOX3, and LOX4 were both upregulated.
      Title: Phytochrome B-mediated activation of lipoxygenase modulates an excess red light-induced defence response in Arabidopsis.
    7. AtLOX-2, AtLOX-3, AtLOX-4 and AtLOX-6 are 13S-lipoxygenases.
      Title: Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001339198.1
    NM_114383.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables linoleate 13S-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within green leaf volatile biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to herbivore IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to other organism TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipoxygenase 2
    NP_566875.1
    • lipoxygenase 2 (LOX2); FUNCTIONS IN: lipoxygenase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast thylakoid membrane, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Lipoxygenase, iron binding site (InterPro:IPR020833), Lipoxygenase, C-terminal (InterPro:IPR013819), Lipoxygenase, LH2 (InterPro:IPR001024), Lipase/lipooxygenase, PLAT/LH2 (InterPro:IPR008976), Lipoxygenase, conserved site (InterPro:IPR020834), Lipoxygenase (InterPro:IPR000907), Lipoxygenase, plant (InterPro:IPR001246); BEST Arabidopsis thaliana protein match is: PLAT/LH2 domain-containing lipoxygenase family protein (TAIR:AT1G67560.1); Has 1459 Blast hits to 1423 proteins in 177 species: Archae - 0; Bacteria - 74; Metazoa - 524; Fungi - 48; Plants - 784; Viruses - 0; Other Eukaryotes - 29 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16525245..16529352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114383.3 → NP_566875.1  lipoxygenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38418, Q0WLR8, Q56WG6, Q8GW45, Q8W4E4, Q9M1U5
      UniProtKB/TrEMBL
      A0A178VJC0
      Conserved Domains (3) summary
      PLN02305
      Location:73 → 896
      PLN02305; lipoxygenase
      cd01751
      Location:73 → 200
      PLAT_LH2; PLAT/ LH2 domain of plant lipoxygenase related proteins. Lipoxygenases are nonheme, nonsulfur iron dioxygenases that act on lipid substrates containing one or more (Z,Z)-1,4-pentadiene moieties. In plants, the immediate products are involved in defense ...
      pfam00305
      Location:211 → 879
      Lipoxygenase; Lipoxygenase

    2. NM_001339198.1 → NP_001326504.1  lipoxygenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJC0, A0A1I9LPH1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38418.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools