PYRD pyrimidine d [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: PYRD
Official Full Name: pyrimidine d
Primary source: TAIR:AT5G23300
Locus tag: AT5G23300
See related: Araport:AT5G23300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DIHYDROOROTATE DEHYDROGENASE; MKD15.16; MKD15_16; pyrimidine d
Summary: dihydroorotate dehydrogenase, catalyses fourth step of pyrimidine biosynthesis
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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NM_122236.3

Function	Evidence Code	Pubs
enables dihydroorotate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydroorotate dehydrogenase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

NP_568428.1

pyrimidine d (PYRD); FUNCTIONS IN: dihydroorotate dehydrogenase activity; INVOLVED IN: 'de novo' pyrimidine base biosynthetic process, pyrimidine ribonucleotide biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Dihydroorotate dehydrogenase, conserved site (InterPro:IPR001295), Aldolase-type TIM barrel (InterPro:IPR013785), Dihydroorotate dehydrogenase, class 2 (InterPro:IPR005719), Dihydroorotate dehydrogenase, class 1/ 2 (InterPro:IPR012135); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).