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    FKBP-type peptidyl-prolyl cis-trans isomerase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834913, updated on 18-Sep-2024

    Summary

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    Official Full Name
    FKBP-type peptidyl-prolyl cis-trans isomerase family protein
    Primary source
    TAIR:AT5G48570
    Locus tag
    AT5G48570
    See related
    Araport:AT5G48570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFKBP65; FKBP65; K15N18.12; K15N18_12; ROF2
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (19690461..19693845, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene mediator of RNA polymerase II transcription subunit-like protein, putative (DUF1216) Neighboring gene FK506- and rapamycin-binding protein 15 kD-2 Neighboring gene phosphoserine aminotransferase, putative (DUF760)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circular dichroism and the secondary structure of the ROF2 protein from Arabidopsis thaliana. Lighezan L, et al. J Biol Phys, 2013 Sep. PMID 23996408, Free PMC Article
    2. Peptidyl-prolyl cis-trans isomerase ROF2 modulates intracellular pH homeostasis in Arabidopsis. Bissoli G, et al. Plant J, 2012 May. PMID 22268595
    3. Involvement of Arabidopsis ROF2 (FKBP65) in thermotolerance. Meiri D, et al. Plant Mol Biol, 2010 Jan. PMID 19876748
    4. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124233.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    FKBP-type peptidyl-prolyl cis-trans isomerase family protein
    NP_199668.1
    • FKBP-type peptidyl-prolyl cis-trans isomerase family protein; FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, calmodulin binding; INVOLVED IN: protein folding; LOCATED IN: vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19690461..19693845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124233.3 → NP_199668.1  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGC2, Q0WSA8, Q9FJL3
      UniProtKB/TrEMBL
      A0A654G964
      Conserved Domains (4) summary
      sd00006
      Location:414 → 438
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:61 → 150
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:493 → 526
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:463 → 524
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJL3.1

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