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    ELF6 Zinc finger (C2H2 type) family protein / transcription factor jumonji (jmj) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830303, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ELF6
    Official Full Name
    Zinc finger (C2H2 type) family protein / transcription factor jumonji (jmj) family protein
    Primary source
    TAIR:AT5G04240
    Locus tag
    AT5G04240
    See related
    Araport:AT5G04240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EARLY FLOWERING 6; F21E1.160; F21E1_160
    Summary
    Early Flowering 6 (ELF6) encodes a Jumonji N/C and zinc finger domain-containing protein that acts as a repressor in the photoperiod pathway. ELF6 interacts with BES1 in a Y2H assay, in vitro, and in Arabidosis protoplasts (based on BiFC). ELF6 may play a role in brassinosteroid signaling by affecting histone methylation in the promoters of BR-responsive genes.
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    Genomic context

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    See ELF6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (1169153..1174992)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phenyl alanine ammonia-lyase 3 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cysteine proteinases superfamily protein Neighboring gene WCRKC thioredoxin 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state. Crevillén P, et al. Nature, 2014 Nov 27. PMID 25219852, Free PMC Article
    2. A new role for histone demethylases in the maintenance of plant genome integrity. Antunez-Sanchez J, et al. Elife, 2020 Oct 27. PMID 33107825, Free PMC Article
    3. Divergent roles of a pair of homologous jumonji/zinc-finger-class transcription factor proteins in the regulation of Arabidopsis flowering time. Noh B, et al. Plant Cell, 2004 Oct. PMID 15377760, Free PMC Article
    4. Repression of FLOWERING LOCUS T chromatin by functionally redundant histone H3 lysine 4 demethylases in Arabidopsis. Jeong JH, et al. PLoS One, 2009 Nov 25. PMID 19946624, Free PMC Article
    5. Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis. Yu X, et al. Proc Natl Acad Sci U S A, 2008 May 27. PMID 18467490, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new role for histone demethylases in the maintenance of plant genome integrity.
      Title: A new role for histone demethylases in the maintenance of plant genome integrity.
    2. AtJmj4 and ELF6 are H3K4 demethylases directly repressing FT chromatin and preventing precocious flowering in Arabidopsis
      Title: Repression of FLOWERING LOCUS T chromatin by functionally redundant histone H3 lysine 4 demethylases in Arabidopsis.
    3. BES1 recruits transcriptional regulators ELF6 and REF6 to regulate target gene expression and coordinate brassinosteroids responses with other developmental processes such as control of flowering time.
      Title: Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120506.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3K27me2/H3K27me3 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of long-day photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of short-day photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect regulation of vernalization response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to brassinosteroid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger (C2H2 type) family protein / transcription factor jumonji (jmj) family protein
    NP_196044.2
    • EARLY FLOWERING 6 (ELF6); CONTAINS InterPro DOMAIN/s: Transcription factor jumonji/aspartyl beta-hydroxylase (InterPro:IPR003347), Zinc finger, C2H2-like (InterPro:IPR015880), Transcription factor jumonji (InterPro:IPR013129), Zinc finger, C2H2-type (InterPro:IPR007087), Transcription factor jumonji, JmjN (InterPro:IPR003349), Zinc finger, C2H2-type/integrase, DNA-binding (InterPro:IPR013087); BEST Arabidopsis thaliana protein match is: relative of early flowering 6 (TAIR:AT3G48430.1); Has 112631 Blast hits to 36360 proteins in 1127 species: Archae - 0; Bacteria - 99; Metazoa - 105700; Fungi - 2573; Plants - 699; Viruses - 11; Other Eukaryotes - 3549 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1169153..1174992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120506.5 → NP_196044.2  Zinc finger (C2H2 type) family protein / transcription factor jumonji (jmj) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196044.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WH6, Q6BDA0, Q9FYD7
      UniProtKB/TrEMBL
      A0A178UAR7, A0A5S9Y1A4, A0A7G2F745
      Conserved Domains (3) summary
      sd00017
      Location:1253 → 1275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02373
      Location:292 → 411
      JmjC; JmjC domain, hydroxylase
      pfam02375
      Location:17 → 50
      JmjN; jmjN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6BDA0.1

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