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    Tlr5 toll-like receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 53791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tlr5provided by MGI
    Official Full Name
    toll-like receptor 5provided by MGI
    Primary source
    MGI:MGI:1858171
    See related
    Ensembl:ENSMUSG00000079164 AllianceGenome:MGI:1858171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Predicted to be involved in inflammatory response; pattern recognition receptor signaling pathway; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; sensory organ; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 1.5), lung adult (RPKM 1.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tlr5 in Genome Data Viewer
    Location:
    1 H5; 1 86.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182782317..182804010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182954752..182976044)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 185 Neighboring gene sushi domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_03290 Neighboring gene STARR-seq mESC enhancer starr_03291 Neighboring gene STARR-seq mESC enhancer starr_03292 Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene predicted gene, 33747 Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node. Flores-Langarica A, et al. J Immunol, 2012 Dec 15. PMID 23152564
    2. Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response. Cao Y, et al. J Leukoc Biol, 2017 Sep. PMID 28522600
    3. Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli. Bens M, et al. Cell Microbiol, 2014 Oct. PMID 24779433
    4. Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy. Mett V, et al. Oncogene, 2018 Jan 25. PMID 28967901, Free PMC Article
    5. Airway structural cells regulate TLR5-mediated mucosal adjuvant activity. Van Maele L, et al. Mucosal Immunol, 2014 May. PMID 24064672

    See all (245) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.
      Title: TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.
    2. Mucosal TLR5 activation controls healthspan and longevity.
      Title: Mucosal TLR5 activation controls healthspan and longevity.
    3. Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
      Title: Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
    4. Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
      Title: Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
    5. Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
      Title: Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
    6. Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
      Title: Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
    7. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation.
      Title: Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation.
    8. Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.
      Title: Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.
    9. Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.
      Title: Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.
    10. Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice.
      Title: Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice.
    Submit: New GeneRIF Correction See all GeneRIFs (118)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in toll-like receptor 5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    toll-like receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016928.4 → NP_058624.3  toll-like receptor 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC170917, FO082331
      Consensus CDS
      CCDS35815.1
      UniProtKB/TrEMBL
      Q05AH3, Q1ZZX0
      Related
      ENSMUSP00000141458.2, ENSMUST00000191820.3
      Conserved Domains (6) summary
      PRK15370
      Location:383 → 583
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:555 → 633
      PCC; polycystin cation channel protein
      sd00033
      Location:291 → 314
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:694 → 844
      TIR; TIR domain
      pfam13855
      Location:294 → 349
      LRR_8; Leucine rich repeat
      cd21340
      Location:92 → 181
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      182782317..182804010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321698.2 → XP_017177187.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    2. XM_017321703.2 → XP_017177192.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Related
      ENSMUSP00000141318.3, ENSMUST00000193687.7
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    3. XM_017321699.3 → XP_017177188.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    4. XM_017321700.3 → XP_017177189.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    5. XM_017321697.3 → XP_017177186.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    6. XM_017321701.2 → XP_017177190.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    7. XM_017321704.2 → XP_017177193.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain

    8. XM_017321702.3 → XP_017177191.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YVY4, Q1ZZX0, Q8CB40
      Conserved Domains (5) summary
      PRK15370
      Location:397 → 597
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:569 → 647
      PCC; polycystin cation channel protein
      sd00033
      Location:305 → 328
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:308 → 363
      LRR_8; Leucine rich repeat
      pfam01582
      Location:708 → 858
      TIR; TIR domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLF7.1 GenPept UniProtKB/Swiss-Prot:Q9JLF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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