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    Rundc3a RUN domain containing 3A [ Mus musculus (house mouse) ]

    Gene ID: 51799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rundc3aprovided by MGI
    Official Full Name
    RUN domain containing 3Aprovided by MGI
    Primary source
    MGI:MGI:1858752
    See related
    Ensembl:ENSMUSG00000006575 AllianceGenome:MGI:1858752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpip8; RPIP-8; Rap2ip
    Summary
    Predicted to be involved in positive regulation of cGMP-mediated signaling. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; gut; nervous system; nose; and retina. Orthologous to human RUNDC3A (RUN domain containing 3A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 61.8), frontal lobe adult (RPKM 60.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rundc3a in Genome Data Viewer
    Location:
    11 D; 11 66.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102284219..102293381)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102393394..102402555)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 (anion exchanger), member 1 Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene STARR-positive B cell enhancer ABC_E11495 Neighboring gene solute carrier family 25, member 39 Neighboring gene STARR-positive B cell enhancer ABC_E5282 Neighboring gene microRNA 6930 Neighboring gene STARR-seq mESC enhancer starr_30808 Neighboring gene STARR-positive B cell enhancers ABC_E9375 and ABC_E8457 Neighboring gene granulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a specific effector of the small GTP-binding protein Rap2. Janoueix-Lerosey I, et al. Eur J Biochem, 1998 Mar 1. PMID 9523700
    2. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. Myagmar BE, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752761
    3. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
    4. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that PARG1 is a putative specific effector of Rap2 to regulate Rho.
      Title: PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RUN domain-containing protein 3A
    Names
    Rap2 interacting protein 8
    rap2-interacting protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252347.2 → NP_001239276.1  RUN domain-containing protein 3A isoform 2

      See identical proteins and their annotated locations for NP_001239276.1

      Status: VALIDATED

      Source sequence(s)
      AL596258, BC046319, BY277835
      Consensus CDS
      CCDS56812.1
      UniProtKB/Swiss-Prot
      O08576
      Related
      ENSMUSP00000102722.3, ENSMUST00000107105.9
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 188
      RUN; RUN domain
      cl09111
      Location:255 → 315
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. NM_001362803.1 → NP_001349732.1  RUN domain-containing protein 3A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596258
      Conserved Domains (1) summary
      pfam02759
      Location:60 → 182
      RUN; RUN domain

    3. NM_001362804.1 → NP_001349733.1  RUN domain-containing protein 3A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596258
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam11180
      Location:263 → 321
      DUF2968; Protein of unknown function (DUF2968)

    4. NM_016759.5 → NP_058039.1  RUN domain-containing protein 3A isoform 1

      See identical proteins and their annotated locations for NP_058039.1

      Status: VALIDATED

      Source sequence(s)
      AK002856, AL596258, BC046319, BY277835
      Consensus CDS
      CCDS25497.1
      UniProtKB/Swiss-Prot
      A2A693, A2A694, O08576, Q80Y95
      Related
      ENSMUSP00000006750.8, ENSMUST00000006750.8
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 188
      RUN; RUN domain
      pfam15898
      Location:267 → 321
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102284219..102293381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533690.2 → XP_006533753.1  RUN domain-containing protein 3A isoform X3

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:255 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    2. XM_006533693.4 → XP_006533756.1  RUN domain-containing protein 3A isoform X10

      UniProtKB/Swiss-Prot
      O08576
      Related
      ENSMUSP00000102719.2, ENSMUST00000107102.8
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 186
      RUN; RUN domain
      pfam06785
      Location:255 → 318
      UPF0242; Uncharacterized protein family (UPF0242)

    3. XM_030246121.2 → XP_030101981.1  RUN domain-containing protein 3A isoform X7

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:250 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    4. XM_006533688.2 → XP_006533751.1  RUN domain-containing protein 3A isoform X1

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 197
      RUN; RUN domain
      pfam06785
      Location:266 → 329
      UPF0242; Uncharacterized protein family (UPF0242)

    5. XM_017314648.3 → XP_017170137.1  RUN domain-containing protein 3A isoform X9

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 197
      RUN; RUN domain
      pfam06785
      Location:266 → 329
      UPF0242; Uncharacterized protein family (UPF0242)

    6. XM_006533689.3 → XP_006533752.1  RUN domain-containing protein 3A isoform X2

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 197
      RUN; RUN domain
      pfam06785
      Location:266 → 329
      UPF0242; Uncharacterized protein family (UPF0242)

    7. XM_006533691.2 → XP_006533754.1  RUN domain-containing protein 3A isoform X4

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 182
      RUN; RUN domain
      pfam06785
      Location:251 → 314
      UPF0242; Uncharacterized protein family (UPF0242)

    8. XM_017314647.3 → XP_017170136.1  RUN domain-containing protein 3A isoform X6

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 182
      RUN; RUN domain
      pfam06785
      Location:251 → 314
      UPF0242; Uncharacterized protein family (UPF0242)

    9. XM_006533692.2 → XP_006533755.1  RUN domain-containing protein 3A isoform X5

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:250 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    10. XM_006533694.4 → XP_006533757.1  RUN domain-containing protein 3A isoform X11

      UniProtKB/Swiss-Prot
      O08576
      Related
      ENSMUSP00000102720.2, ENSMUST00000107103.8
      Conserved Domains (2) summary
      pfam02759
      Location:60 → 181
      RUN; RUN domain
      pfam06785
      Location:250 → 313
      UPF0242; Uncharacterized protein family (UPF0242)

    11. XM_011249124.2 → XP_011247426.1  RUN domain-containing protein 3A isoform X8

      Conserved Domains (2) summary
      pfam02759
      Location:60 → 197
      RUN; RUN domain
      pfam06785
      Location:266 → 329
      UPF0242; Uncharacterized protein family (UPF0242)

    RNA

    1. XR_003949474.2 RNA Sequence

    2. XR_003949475.2 RNA Sequence

    3. XR_001780024.2 RNA Sequence

    4. XR_003949473.2 RNA Sequence

    5. XR_004936988.1 RNA Sequence

    6. XR_003949476.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08576.1 GenPept UniProtKB/Swiss-Prot:O08576

    Gene LinkOut

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