U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cadps Ca2+-dependent secretion activator [ Mus musculus (house mouse) ]

    Gene ID: 27062, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cadpsprovided by MGI
    Official Full Name
    Ca2+-dependent secretion activatorprovided by MGI
    Primary source
    MGI:MGI:1350922
    See related
    Ensembl:ENSMUSG00000054423 AllianceGenome:MGI:1350922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAPS; CAPS1; mKIAA1121
    Summary
    Enables protein kinase binding activity. Involved in presynaptic dense core vesicle exocytosis and synaptic vesicle priming. Acts upstream of or within catecholamine secretion; establishment of localization in cell; and vesicle organization. Located in cytoplasmic vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; heart; nervous system; olfactory epithelium; and retina. Orthologous to human CADPS (calcium dependent secretion activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 23.4), cerebellum adult (RPKM 20.6) and 5 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cadps in Genome Data Viewer
    Location:
    14 A1; 14 6.37 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (9646424..10097203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (12372560..12823339, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35969 Neighboring gene predicted gene 5087 Neighboring gene STARR-seq mESC enhancer starr_35968 Neighboring gene STARR-seq mESC enhancer starr_35966 Neighboring gene STARR-seq mESC enhancer starr_35965 Neighboring gene STARR-seq mESC enhancer starr_35964 Neighboring gene STARR-seq mESC enhancer starr_35963 Neighboring gene STARR-seq mESC enhancer starr_35962 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_35960 Neighboring gene STARR-seq mESC enhancer starr_35958 Neighboring gene STARR-seq mESC enhancer starr_35957 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35956 Neighboring gene predicted gene, 24578 Neighboring gene Fez family zinc finger 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Miyake K, et al. Cell Rep, 2016 Nov 15. PMID 27851964, Free PMC Article
    2. Interaction of Ca(2+)-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Hosono M, et al. Neurosci Lett, 2016 Mar 23. PMID 26917099
    3. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. Shumate KM, et al. J Neurochem, 2021 Jul. PMID 33894004, Free PMC Article
    4. CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons. Eckenstaler R, et al. J Cell Sci, 2016 Apr 1. PMID 26869227
    5. CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. Liu Y, et al. J Neurosci, 2008 May 21. PMID 18495893, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
      Title: CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
    2. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
      Title: RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
    3. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning.
      Title: CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning.
    4. The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
      Title: The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
    5. CAPS1 promotes colorectal cancer metastasis through PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial mesenchymal transformation process
      Title: CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation.
    6. Together, these data show that the CAPS-1 C-terminus regulates synaptic enrichment of CAPS-1. All CAPS-1 functional domains are required, and the C2 and PH domain together are not sufficient, for dense core vesicles exocytosis in mammalian central nervous system neurons.
      Title: CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.
    7. findings suggest that CAPS1 stabilizes the state of readily releasable synaptic vesicles, thereby enhancing neurotransmitter release at hippocampal synapses.
      Title: CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus.
    8. edited CAPS1 bound preferentially to the activated form of syntaxin-1A, a component of the exocytotic fusion complex.
      Title: CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.
    9. CAPS1 protein plays an important role during protein release from secretory granules in hippocampal neurons. The cytosolic protein CAPS1 regulates several stages of secretory granule processing.
      Title: CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons.
    10. identified a specific interaction of CAPS1 with septin family proteins; demonstrated that the C-terminal region of the CAPS1 protein binds to part of the deduced GTP-binding domain of septin proteins.
      Title: Interaction of Ca(2+)-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC90712

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within catecholamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic dense core vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic vesicle priming IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of neuronal dense core vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal dense core vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    calcium-dependent secretion activator 1
    Names
    Ca2+-dependent activator protein for secretion
    Ca<2+>dependent activator protein for secretion
    calcium-dependent activator protein for secretion 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042617.1 → NP_001036082.1  calcium-dependent secretion activator 1 isoform 2

      See identical proteins and their annotated locations for NP_001036082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is 6 aa shorter than isoform 1.
      Source sequence(s)
      AC116395, AK122453, BC079679
      Consensus CDS
      CCDS36807.1
      UniProtKB/Swiss-Prot
      E9QN90, Q3TSP2, Q61374, Q6AXB4, Q6PGF0, Q80TJ1
      Related
      ENSMUSP00000108277.2, ENSMUST00000112658.8
      Conserved Domains (4) summary
      smart00239
      Location:397 → 480
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:521 → 620
      PH; PH domain
      pfam06292
      Location:838 → 942
      DUF1041; Domain of Unknown Function (DUF1041)

    2. NM_001359919.1 → NP_001346848.1  calcium-dependent secretion activator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116395, AC154592, AC156025, AV298053, BE950560, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 938
      DUF1041; Domain of Unknown Function (DUF1041)

    3. NM_001359920.1 → NP_001346849.1  calcium-dependent secretion activator 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116395, AC154592, AC156025, AV298053, BE950560, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 932
      DUF1041; Domain of Unknown Function (DUF1041)

    4. NM_001359921.1 → NP_001346850.1  calcium-dependent secretion activator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116395, AC154592, AC156025, AV298053, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 961
      DUF1041; Domain of Unknown Function (DUF1041)

    5. NM_012061.3 → NP_036191.2  calcium-dependent secretion activator 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC116395, AC156025, AK133310, BQ715095, CB245630, CB527086, CF539197, CX238199
      Consensus CDS
      CCDS36806.1
      Related
      ENSMUSP00000064706.7, ENSMUST00000067491.14
      Conserved Domains (4) summary
      smart00239
      Location:397 → 480
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:521 → 620
      PH; PH domain
      pfam06292
      Location:834 → 948
      DUF1041; Domain of Unknown Function (DUF1041)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      9646424..10097203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158614.1 → XP_036014507.1  calcium-dependent secretion activator 1 isoform X1

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1021
      DUF1041; Domain of Unknown Function (DUF1041)

    2. XM_036158620.1 → XP_036014513.1  calcium-dependent secretion activator 1 isoform X7

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1021
      DUF1041; Domain of Unknown Function (DUF1041)

    3. XM_036158630.1 → XP_036014523.1  calcium-dependent secretion activator 1 isoform X16

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1021
      DUF1041; Domain of Unknown Function (DUF1041)

    4. XM_036158618.1 → XP_036014511.1  calcium-dependent secretion activator 1 isoform X5

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1014
      DUF1041; Domain of Unknown Function (DUF1041)

    5. XM_036158631.1 → XP_036014524.1  calcium-dependent secretion activator 1 isoform X18

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1014
      DUF1041; Domain of Unknown Function (DUF1041)

    6. XM_036158615.1 → XP_036014508.1  calcium-dependent secretion activator 1 isoform X2

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1018
      DUF1041; Domain of Unknown Function (DUF1041)

    7. XM_036158619.1 → XP_036014512.1  calcium-dependent secretion activator 1 isoform X6

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1011
      DUF1041; Domain of Unknown Function (DUF1041)

    8. XM_036158632.1 → XP_036014525.1  calcium-dependent secretion activator 1 isoform X20

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1011
      DUF1041; Domain of Unknown Function (DUF1041)

    9. XM_036158617.1 → XP_036014510.1  calcium-dependent secretion activator 1 isoform X4

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1015
      DUF1041; Domain of Unknown Function (DUF1041)

    10. XM_036158621.1 → XP_036014514.1  calcium-dependent secretion activator 1 isoform X8

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1005
      DUF1041; Domain of Unknown Function (DUF1041)

    11. XM_036158634.1 → XP_036014527.1  calcium-dependent secretion activator 1 isoform X23

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 1005
      DUF1041; Domain of Unknown Function (DUF1041)

    12. XM_036158622.1 → XP_036014515.1  calcium-dependent secretion activator 1 isoform X9

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 998
      DUF1041; Domain of Unknown Function (DUF1041)

    13. XM_036158626.1 → XP_036014519.1  calcium-dependent secretion activator 1 isoform X12

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 991
      DUF1041; Domain of Unknown Function (DUF1041)

    14. XM_036158624.1 → XP_036014517.1  calcium-dependent secretion activator 1 isoform X10

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 995
      DUF1041; Domain of Unknown Function (DUF1041)

    15. XM_036158627.1 → XP_036014520.1  calcium-dependent secretion activator 1 isoform X13

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 988
      DUF1041; Domain of Unknown Function (DUF1041)

    16. XM_036158625.1 → XP_036014518.1  calcium-dependent secretion activator 1 isoform X11

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 992
      DUF1041; Domain of Unknown Function (DUF1041)

    17. XM_036158629.1 → XP_036014522.1  calcium-dependent secretion activator 1 isoform X15

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 982
      DUF1041; Domain of Unknown Function (DUF1041)

    18. XM_036158638.1 → XP_036014531.1  calcium-dependent secretion activator 1 isoform X30

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:891 → 982
      DUF1041; Domain of Unknown Function (DUF1041)

    19. XM_006518024.5 → XP_006518087.1  calcium-dependent secretion activator 1 isoform X17

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 966
      DUF1041; Domain of Unknown Function (DUF1041)

    20. XM_006518029.5 → XP_006518092.1  calcium-dependent secretion activator 1 isoform X21

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 956
      DUF1041; Domain of Unknown Function (DUF1041)

    21. XM_017316035.3 → XP_017171524.1  calcium-dependent secretion activator 1 isoform X35

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 956
      DUF1041; Domain of Unknown Function (DUF1041)

    22. XM_006518031.5 → XP_006518094.1  calcium-dependent secretion activator 1 isoform X25

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 950
      DUF1041; Domain of Unknown Function (DUF1041)

    23. XM_017316037.3 → XP_017171526.1  calcium-dependent secretion activator 1 isoform X37

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 950
      DUF1041; Domain of Unknown Function (DUF1041)

    24. XM_006518032.5 → XP_006518095.1  calcium-dependent secretion activator 1 isoform X26

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 943
      DUF1041; Domain of Unknown Function (DUF1041)

    25. XM_036158641.1 → XP_036014534.1  calcium-dependent secretion activator 1 isoform X39

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 942
      DUF1041; Domain of Unknown Function (DUF1041)

    26. XM_036158637.1 → XP_036014530.1  calcium-dependent secretion activator 1 isoform X29

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 935
      DUF1041; Domain of Unknown Function (DUF1041)

    27. XM_006518036.5 → XP_006518099.1  calcium-dependent secretion activator 1 isoform X31

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 930
      DUF1041; Domain of Unknown Function (DUF1041)

    28. XM_030247840.2 → XP_030103700.1  calcium-dependent secretion activator 1 isoform X40

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 930
      DUF1041; Domain of Unknown Function (DUF1041)

    29. XM_030247838.2 → XP_030103698.1  calcium-dependent secretion activator 1 isoform X33

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 927
      DUF1041; Domain of Unknown Function (DUF1041)

    30. XM_006518043.5 → XP_006518106.1  calcium-dependent secretion activator 1 isoform X42

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:838 → 927
      DUF1041; Domain of Unknown Function (DUF1041)

    31. XM_036158616.1 → XP_036014509.1  calcium-dependent secretion activator 1 isoform X3

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:887 → 1017
      DUF1041; Domain of Unknown Function (DUF1041)

    32. XM_036158633.1 → XP_036014526.1  calcium-dependent secretion activator 1 isoform X22

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:887 → 1007
      DUF1041; Domain of Unknown Function (DUF1041)

    33. XM_036158628.1 → XP_036014521.1  calcium-dependent secretion activator 1 isoform X14

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:887 → 988
      DUF1041; Domain of Unknown Function (DUF1041)

    34. XM_006518048.4 → XP_006518111.1  calcium-dependent secretion activator 1 isoform X34

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:887 → 976
      DUF1041; Domain of Unknown Function (DUF1041)

    35. XM_006518026.5 → XP_006518089.1  calcium-dependent secretion activator 1 isoform X19

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 962
      DUF1041; Domain of Unknown Function (DUF1041)

    36. XM_036158635.1 → XP_036014528.1  calcium-dependent secretion activator 1 isoform X24

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 954
      DUF1041; Domain of Unknown Function (DUF1041)

    37. XM_036158640.1 → XP_036014533.1  calcium-dependent secretion activator 1 isoform X36

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 954
      DUF1041; Domain of Unknown Function (DUF1041)

    38. XM_006518041.5 → XP_006518104.1  calcium-dependent secretion activator 1 isoform X38

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 946
      DUF1041; Domain of Unknown Function (DUF1041)

    39. XM_036158636.1 → XP_036014529.1  calcium-dependent secretion activator 1 isoform X27

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 941
      DUF1041; Domain of Unknown Function (DUF1041)

    40. XM_006518034.5 → XP_006518097.1  calcium-dependent secretion activator 1 isoform X28

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 936
      DUF1041; Domain of Unknown Function (DUF1041)

    41. XM_036158639.1 → XP_036014532.1  calcium-dependent secretion activator 1 isoform X32

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 931
      DUF1041; Domain of Unknown Function (DUF1041)

    42. XM_017316038.3 → XP_017171527.1  calcium-dependent secretion activator 1 isoform X41

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 929
      DUF1041; Domain of Unknown Function (DUF1041)

    43. XM_006518044.5 → XP_006518107.1  calcium-dependent secretion activator 1 isoform X43

      Conserved Domains (2) summary
      cd01234
      Location:513 → 632
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:834 → 923
      DUF1041; Domain of Unknown Function (DUF1041)

    RNA

    1. XR_004938408.1 RNA Sequence

    2. XR_004938409.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TJ1.3 GenPept UniProtKB/Swiss-Prot:Q80TJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools