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    Pgd phosphogluconate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 110208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgdprovided by MGI
    Official Full Name
    phosphogluconate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:97553
    See related
    Ensembl:ENSMUSG00000028961 AllianceGenome:MGI:97553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610042A05Rik
    Summary
    Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within pentose biosynthetic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; axial musculature; liver; and orbito-sphenoid. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 156.7), mammary gland adult (RPKM 135.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgd in Genome Data Viewer
    Location:
    4 E2; 4 78.96 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149234448..149251162, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149149991..149166705, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4730 Neighboring gene STARR-positive B cell enhancer ABC_E11279 Neighboring gene STARR-positive B cell enhancer ABC_E4731 Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene centromere protein S Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The modulation of the oxidative phase of the pentose phosphate pathway in mouse liver. Velasco P, et al. Int J Biochem Cell Biol, 1995 Oct. PMID 7496990
    2. Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function. Daneshmandi S, et al. Cell Rep, 2021 Mar 9. PMID 33691103, Free PMC Article
    3. Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c. Rho HK, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896329
    4. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. Sukhatme VP, et al. FEBS Lett, 2012 Jul 30. PMID 22677172
    5. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Gao X, et al. Mol Cell, 2019 Dec 19. PMID 31586547, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function.
      Title: Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function.
    2. 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
      Title: 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
    3. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
      Title: Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
    4. Taken together, these data suggest that ADD1/SREBP1c is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.
      Title: Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphogluconate dehydrogenase (decarboxylating) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphogluconate dehydrogenase (decarboxylating) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-gluconate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-gluconate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-gluconate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pentose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-phosphogluconate dehydrogenase, decarboxylating
    NP_001074743.1
    NP_001343261.1
    XP_006538535.1
    XP_030108942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081274.2 → NP_001074743.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 1

      See identical proteins and their annotated locations for NP_001074743.1

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, CX212251, CX215938
      Consensus CDS
      CCDS38974.1
      UniProtKB/Swiss-Prot
      Q3UD80, Q9DCD0
      UniProtKB/TrEMBL
      Q91V28
      Related
      ENSMUSP00000081141.7, ENSMUST00000084124.7
      Conserved Domains (3) summary
      PRK09287
      Location:14 → 470
      PRK09287; 6-phosphogluconate dehydrogenase; Validated
      pfam00393
      Location:180 → 469
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
      pfam03446
      Location:3 → 176
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase

    2. NM_001356332.1 → NP_001343261.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, AL731655, CX212251
      Conserved Domains (1) summary
      pfam00393
      Location:1 → 285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149234448..149251162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253082.2 → XP_030108942.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1 → 285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    2. XM_006538472.4 → XP_006538535.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1 → 285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025801.1: Suppressed sequence

      Description
      NM_025801.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCD0.3 GenPept UniProtKB/Swiss-Prot:Q9DCD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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