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    Dennd4c DENN domain containing 4C [ Mus musculus (house mouse) ]

    Gene ID: 329877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dennd4cprovided by MGI
    Official Full Name
    DENN domain containing 4Cprovided by MGI
    Primary source
    MGI:MGI:1914769
    See related
    Ensembl:ENSMUSG00000038024 AllianceGenome:MGI:1914769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700065A05Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in cellular response to insulin stimulus and protein localization to plasma membrane. Located in cytosol; insulin-responsive compartment; and plasma membrane. Part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.8), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd4c in Genome Data Viewer
    Location:
    4 C4; 4 40.69 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86666761..86768841)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86748518..86850603)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10694 Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2 Neighboring gene STARR-seq mESC enhancer starr_10695 Neighboring gene STARR-seq mESC enhancer starr_10697 Neighboring gene STARR-seq mESC enhancer starr_10698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:86358735-86358844 Neighboring gene predicted gene, 42312 Neighboring gene STARR-positive B cell enhancer ABC_E7973 Neighboring gene predicted gene 6521 Neighboring gene STARR-seq mESC enhancer starr_10700 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10701 Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene ribosomal protein S6 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene alkaline ceramidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
    2. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. Sano H, et al. J Biol Chem, 2011 May 13. PMID 21454697, Free PMC Article
    3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
      Title: Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DENN domain-containing protein 4C
    Names
    DENN/MADD domain containing 4C
    likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405424.1 → NP_001392353.1  DENN domain-containing protein 4C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772228, BX005084
      UniProtKB/TrEMBL
      E9Q449
      Related
      ENSMUSP00000080685.7, ENSMUST00000082026.14

    2. NM_001405425.1 → NP_001392354.1  DENN domain-containing protein 4C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL772228, BX005084
      UniProtKB/Swiss-Prot
      A2AJX5, A6H8H2, Q3U2K9
      UniProtKB/TrEMBL
      E9Q449

    3. NM_184088.2 → NP_908976.1  DENN domain-containing protein 4C isoform 1

      See identical proteins and their annotated locations for NP_908976.1

      Status: VALIDATED

      Source sequence(s)
      AL772228, BX005084
      Consensus CDS
      CCDS51218.2
      UniProtKB/Swiss-Prot
      A2AJX5, A6H8H2, Q3U2K9
      UniProtKB/TrEMBL
      E9Q449
      Related
      ENSMUSP00000123367.3, ENSMUST00000142837.3
      Conserved Domains (4) summary
      smart00801
      Location:558 → 631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819 → 848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308 → 491
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86666761..86768841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538023.4 → XP_006538086.1  DENN domain-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_006538086.1

      UniProtKB/TrEMBL
      E9Q449
      Related
      ENSMUSP00000039860.9, ENSMUST00000045512.15
      Conserved Domains (4) summary
      smart00801
      Location:558 → 631
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:192 → 275
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:819 → 848
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308 → 491
      DENN; DENN (AEX-3) domain

    2. XM_006538024.4 → XP_006538087.1  DENN domain-containing protein 4C isoform X3

      Conserved Domains (4) summary
      smart00801
      Location:323 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584 → 613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73 → 256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:1 → 40
      uDENN; uDENN domain

    3. XM_006538025.4 → XP_006538088.1  DENN domain-containing protein 4C isoform X4

    RNA

    1. XR_390327.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081014.1: Suppressed sequence

      Description
      NM_001081014.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H8H2.1 GenPept UniProtKB/Swiss-Prot:A6H8H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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