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    Serf2 small EDRK-rich factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 378702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serf2provided by MGI
    Official Full Name
    small EDRK-rich factor 2provided by MGI
    Primary source
    MGI:MGI:1337041
    See related
    Ensembl:ENSMUSG00000074884 AllianceGenome:MGI:1337041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msmac1l; m4F5rel
    Summary
    Predicted to be involved in protein destabilization. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including brain; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Orthologous to human SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 128.1), large intestine adult (RPKM 95.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serf2 in Genome Data Viewer
    Location:
    2 E5; 2 60.39 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121279679..121283901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121449198..121453420)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene serine incorporator 4 Neighboring gene huntingtin interacting protein K Neighboring gene microfibrillar-associated protein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits. Cleverley K, et al. Mamm Genome, 2021 Apr. PMID 33713180, Free PMC Article
    2. Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Stroo E, et al. Life Sci Alliance, 2023 Jul. PMID 37130781, Free PMC Article
    3. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Scharf JM, et al. Nat Genet, 1998 Sep. PMID 9731538
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
      Title: Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
    2. A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
      Title: A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    small EDRK-rich factor 2
    Names
    4F5rel (4F5 related)
    protein 4F5-related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290837.1 → NP_001277766.1  small EDRK-rich factor 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK132746, BP768998, BY070249, CJ073462
      Consensus CDS
      CCDS71126.1
      UniProtKB/TrEMBL
      A2ARQ4
      Related
      ENSMUSP00000097074.5, ENSMUST00000099475.12
      Conserved Domains (1) summary
      pfam04419
      Location:1 → 37
      4F5; 4F5 protein family

    2. NM_011354.3 → NP_035484.1  small EDRK-rich factor 2 isoform b

      See identical proteins and their annotated locations for NP_035484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK132746, BP768998, CJ073462
      Consensus CDS
      CCDS16645.1
      UniProtKB/Swiss-Prot
      A2ARQ3, P84102
      UniProtKB/TrEMBL
      Q58DZ4
      Related
      ENSMUSP00000123181.2, ENSMUST00000139253.8
      Conserved Domains (1) summary
      pfam04419
      Location:1 → 37
      4F5; 4F5 protein family

    RNA

    1. NR_110986.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA423654, AK132746, BP768998, CJ073462

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121279679..121283901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84102.1 GenPept UniProtKB/Swiss-Prot:P84102

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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