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    Rpl38 ribosomal protein L38 [ Mus musculus (house mouse) ]

    Gene ID: 67671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpl38provided by MGI
    Official Full Name
    ribosomal protein L38provided by MGI
    Primary source
    MGI:MGI:1914921
    See related
    Ensembl:ENSMUSG00000057322 AllianceGenome:MGI:1914921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ts; Rbt; Tss; 0610025G13Rik
    Summary
    A structural constituent of ribosome. Acts upstream of or within several processes, including 90S preribosome assembly; middle ear morphogenesis; and sensory perception of sound. Located in cytoplasm. Part of cytosolic large ribosomal subunit and eukaryotic 80S initiation complex. Is active in synapse. Is expressed in thymus primordium. Used to study otitis media. Orthologous to human RPL38 (ribosomal protein L38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 322.3), liver E14 (RPKM 265.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl38 in Genome Data Viewer
    Location:
    11 79.82 cM; 11 E2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114558644..114563159)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114667818..114672333)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53653 Neighboring gene STARR-positive B cell enhancer ABC_E1151 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene tweety family member 2 Neighboring gene dynein axonemal intermediate chain 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114606533-114606834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis. Shi L, et al. Inflamm Res, 2022 Aug. PMID 35596790
    2. Fetal erythropoiesis and hemoglobin ontogeny in tail-short (Ts/+) mutant mice. Brotherton TW, et al. Blood, 1979 Sep. PMID 465735
    3. In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse. Paterson HF. J Exp Zool, 1980 Feb. PMID 7373273
    4. A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. MORGAN WC. J Hered, 1950 Aug. PMID 14779008
    5. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. Noben-Trauth K, et al. J Biol Chem, 2011 Jan 28. PMID 21062742, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis.
      Title: RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis.
    2. Study identified mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of the axial skeleton.
      Title: Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.
    3. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.
      Title: Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 90S preribosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within axial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within middle ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-RNA complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 80S initiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL38
    Names
    60S ribosomal protein L38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048057.2 → NP_001041522.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_001041522.1

      Status: VALIDATED

      Source sequence(s)
      AL645484, BC094258, BU921494, CJ042718
      Consensus CDS
      CCDS36365.1
      UniProtKB/Swiss-Prot
      Q9JJI8
      UniProtKB/TrEMBL
      Q52KP0
      Related
      ENSMUSP00000102211.2, ENSMUST00000077915.10
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    2. NM_001048058.2 → NP_001041523.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_001041523.1

      Status: VALIDATED

      Source sequence(s)
      AL645484, BE448083
      Consensus CDS
      CCDS36365.1
      UniProtKB/Swiss-Prot
      Q9JJI8
      UniProtKB/TrEMBL
      Q52KP0
      Related
      ENSMUSP00000080741.5, ENSMUST00000082092.5
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    3. NM_001362918.1 → NP_001349847.1  large ribosomal subunit protein eL38

      Status: VALIDATED

      Source sequence(s)
      AL645484, BY687415
      Consensus CDS
      CCDS36365.1
      UniProtKB/Swiss-Prot
      Q9JJI8
      UniProtKB/TrEMBL
      Q52KP0
      Related
      ENSMUSP00000102209.2, ENSMUST00000106599.8
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    4. NM_023372.3 → NP_075861.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_075861.1

      Status: VALIDATED

      Source sequence(s)
      AL645484, BC094258, BU921494
      Consensus CDS
      CCDS36365.1
      UniProtKB/Swiss-Prot
      Q9JJI8
      UniProtKB/TrEMBL
      Q52KP0
      Related
      ENSMUSP00000102213.4, ENSMUST00000106602.10
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114558644..114563159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314720.1 → XP_017170209.1  large ribosomal subunit protein eL38 isoform X1

      UniProtKB/Swiss-Prot
      Q9JJI8
      UniProtKB/TrEMBL
      Q52KP0
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJI8.3 GenPept UniProtKB/Swiss-Prot:Q9JJI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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