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    Ankra2 ankyrin repeat family A member 2 [ Mus musculus (house mouse) ]

    Gene ID: 68558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankra2provided by MGI
    Official Full Name
    ankyrin repeat family A member 2provided by MGI
    Primary source
    MGI:MGI:1915808
    See related
    Ensembl:ENSMUSG00000021661 AllianceGenome:MGI:1915808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankra; 1110004M18Rik
    Summary
    Enables histone deacetylase binding activity. Predicted to be involved in regulation of gene expression and regulation of protein-containing complex assembly. Located in cytoplasm; membrane; and nucleus. Is expressed in main olfactory bulb. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.9), CNS E14 (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankra2 in Genome Data Viewer
    Location:
    13 D1; 13 51.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98399584..98411262)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98263076..98274754)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 28 Neighboring gene predicted gene, 34469 Neighboring gene STARR-seq mESC enhancer starr_35415 Neighboring gene STARR-positive B cell enhancer ABC_E5411 Neighboring gene UTP15 small subunit processome component Neighboring gene STARR-seq mESC enhancer starr_35417 Neighboring gene predicted gene 21976 Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene basic transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2. Long AB, et al. Immunogenetics, 2005 Feb. PMID 15655668
    2. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-->q13 by radiation hybrid mapping and somatic cell hybrid PCR. Rader K, et al. Cytogenet Cell Genet, 2000. PMID 10965114
    3. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. Rader K, et al. J Am Soc Nephrol, 2000 Dec. PMID 11095640
    4. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. McKinsey TA, et al. Mol Biol Cell, 2006 Jan. PMID 16236793, Free PMC Article
    5. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. Wang AH, et al. J Biol Chem, 2005 Aug 12. PMID 15964851

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 3M complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of 3M complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat family A protein 2
    Names
    RFXANK-like protein 2
    ankyrin repeat, family A (RFXANK-like), 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271388.1 → NP_001258317.1  ankyrin repeat family A protein 2 isoform a

      See identical proteins and their annotated locations for NP_001258317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AC123056, AK139343, AK161446, BE952624
      Consensus CDS
      CCDS70493.1
      UniProtKB/TrEMBL
      Q3UTL3, Q6NZJ1
      Related
      ENSMUSP00000122701.2, ENSMUST00000123924.8
      Conserved Domains (3) summary
      cd00204
      Location:175 → 292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185 → 276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180 → 211
      ANK; ANK repeat [structural motif]

    2. NM_001271389.1 → NP_001258318.1  ankyrin repeat family A protein 2 isoform b

      See identical proteins and their annotated locations for NP_001258318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK161446, BC079615
      Consensus CDS
      CCDS70492.1
      UniProtKB/TrEMBL
      Q3UTL3, Q6AXE4
      Related
      ENSMUSP00000117508.2, ENSMUST00000150352.3
      Conserved Domains (3) summary
      cd00204
      Location:175 → 292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185 → 276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180 → 211
      ANK; ANK repeat [structural motif]

    3. NM_001271390.1 → NP_001258319.1  ankyrin repeat family A protein 2 isoform c

      See identical proteins and their annotated locations for NP_001258319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AK081695, AK161446, BE952624
      Consensus CDS
      CCDS70494.1
      UniProtKB/TrEMBL
      Q8C4M9
      Related
      ENSMUSP00000088915.4, ENSMUST00000091356.11
      Conserved Domains (4) summary
      COG0666
      Location:1 → 42
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:15 → 132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:25 → 116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:20 → 51
      ANK; ANK repeat [structural motif]

    4. NM_001271391.1 → NP_001258320.1  ankyrin repeat family A protein 2 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK003438, AK161446, BE952624, BF730624
      Consensus CDS
      CCDS88506.1
      UniProtKB/TrEMBL
      A0A286YDH7
      Related
      ENSMUSP00000153417.2, ENSMUST00000226100.2
      Conserved Domains (2) summary
      sd00045
      Location:20 → 51
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:25 → 115
      Ank_2; Ankyrin repeats (3 copies)

    5. NM_001271392.1 → NP_001258321.1  ankyrin repeat family A protein 2 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK003438, AK161446, BE952624
      Consensus CDS
      CCDS88507.1
      UniProtKB/TrEMBL
      D3Z4I1
      Related
      ENSMUSP00000116590.3, ENSMUST00000150916.9
      Conserved Domains (4) summary
      COG0666
      Location:1 → 42
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:15 → 132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:25 → 116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:20 → 51
      ANK; ANK repeat [structural motif]

    6. NM_023472.2 → NP_075961.1  ankyrin repeat family A protein 2 isoform d

      See identical proteins and their annotated locations for NP_075961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK161446, BC079615, BE952624, BF730624
      Consensus CDS
      CCDS26713.1
      UniProtKB/Swiss-Prot
      Q99PE2
      UniProtKB/TrEMBL
      Q3UTL3
      Related
      ENSMUSP00000022164.9, ENSMUST00000022164.16
      Conserved Domains (3) summary
      cd00204
      Location:175 → 295
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185 → 276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180 → 211
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98399584..98411262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315580.2 → XP_017171069.1  ankyrin repeat family A protein 2 isoform X1

      Conserved Domains (2) summary
      sd00045
      Location:113 → 144
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:118 → 208
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PE2.1 GenPept UniProtKB/Swiss-Prot:Q99PE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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