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    Fbxo15 F-box protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 50764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo15provided by MGI
    Official Full Name
    F-box protein 15provided by MGI
    Primary source
    MGI:MGI:1354755
    See related
    Ensembl:ENSMUSG00000034391 AllianceGenome:MGI:1354755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx15; ecat3
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including early embryo; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human FBXO15 (F-box protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.7) and placenta adult (RPKM 0.2) See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo15 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84952677..84999601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84934552..84981476)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene, 17266 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:85043680-85043998 Neighboring gene STARR-seq mESC enhancer starr_45258 Neighboring gene predicted gene 16146 Neighboring gene STARR-positive B cell enhancer ABC_E11009 Neighboring gene STARR-seq mESC enhancer starr_45265 Neighboring gene cytochrome b5 type A (microsomal) Neighboring gene STARR-seq mESC enhancer starr_45275 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene STARR-seq mESC enhancer starr_45276 Neighboring gene STARR-seq mESC enhancer starr_45277 Neighboring gene STARR-seq mESC enhancer starr_45279 Neighboring gene predicted gene, 32291 Neighboring gene predicted gene 7612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15. Zhang Z, et al. Sci Rep, 2020 Nov 6. PMID 33159144, Free PMC Article
    2. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Donato V, et al. Nat Cell Biol, 2017 Apr. PMID 28319092, Free PMC Article
    3. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Chen BB, et al. Cell Rep, 2014 Apr 24. PMID 24703837, Free PMC Article
    4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
    5. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Han DW, et al. Cell, 2010 Nov 12. PMID 21056461

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.
      Title: Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15.
    2. TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
      Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
    3. Fbxo15 mediates degradation of cardiolipin synthase1 in pneumonia.
      Title: E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.
    4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal, development, and fertility.
      Title: Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367965.1 → NP_001354894.1  F-box only protein 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128672, AC134545
      Consensus CDS
      CCDS89296.1
      UniProtKB/Swiss-Prot
      Q9QZN0
      UniProtKB/TrEMBL
      A0A494BAM1
      Related
      ENSMUSP00000158102.2, ENSMUST00000223789.3

    2. NM_015798.5 → NP_056613.2  F-box only protein 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK166591, AK167270
      Consensus CDS
      CCDS37877.2
      UniProtKB/Swiss-Prot
      Q9QZN0
      UniProtKB/TrEMBL
      A0A286YDM4
      Related
      ENSMUSP00000153473.2, ENSMUST00000224467.3
      Conserved Domains (1) summary
      pfam12937
      Location:2 → 42
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84952677..84999601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247086.1 → XP_011245388.1  F-box only protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011245388.1

      UniProtKB/Swiss-Prot
      Q9QZN0
      UniProtKB/TrEMBL
      Q3TJW2
      Related
      ENSMUSP00000045925.10, ENSMUST00000037718.10
      Conserved Domains (1) summary
      pfam12937
      Location:43 → 87
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZN0.2 GenPept UniProtKB/Swiss-Prot:Q9QZN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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