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    Eml6 echinoderm microtubule associated protein like 6 [ Mus musculus (house mouse) ]

    Gene ID: 237711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eml6provided by MGI
    Official Full Name
    echinoderm microtubule associated protein like 6provided by MGI
    Primary source
    MGI:MGI:2442895
    See related
    Ensembl:ENSMUSG00000044072 AllianceGenome:MGI:2442895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMAP-6; 2900083P10Rik; C230094A16Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Is expressed in nervous system and sensory organ. Orthologous to human EML6 (EMAP like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 7.3), CNS E11.5 (RPKM 7.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eml6 in Genome Data Viewer
    Location:
    11 A3.3; 11 16.83 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29693044..29976044, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29743044..30026045, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29028 Neighboring gene STARR-positive B cell enhancer ABC_E3937 Neighboring gene STARR-seq mESC enhancer starr_29030 Neighboring gene predicted gene 12092 Neighboring gene predicted gene, 53675 Neighboring gene STARR-seq mESC enhancer starr_29032 Neighboring gene STARR-seq mESC enhancer starr_29033 Neighboring gene STARR-seq mESC enhancer starr_29034 Neighboring gene STARR-positive B cell enhancer ABC_E2351 Neighboring gene STARR-seq mESC enhancer starr_29036 Neighboring gene STARR-seq mESC enhancer starr_29037 Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29038 Neighboring gene reticulon 4 Neighboring gene predicted gene, 39671 Neighboring gene STARR-seq mESC enhancer starr_29040 Neighboring gene STARR-seq mESC enhancer starr_29041 Neighboring gene fem-1 homolog A like Neighboring gene STARR-seq mESC enhancer starr_29042 Neighboring gene STARR-seq mESC enhancer starr_29043 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 22588 Neighboring gene STARR-seq mESC enhancer starr_29044 Neighboring gene predicted gene 12095 Neighboring gene STARR-seq mESC enhancer starr_29045 Neighboring gene STARR-seq mESC enhancer starr_29046 Neighboring gene spectrin beta, non-erythrocytic 1 Neighboring gene STARR-seq mESC enhancer starr_29049 Neighboring gene STARR-seq mESC enhancer starr_29053 Neighboring gene STARR-seq mESC enhancer starr_29054 Neighboring gene predicted gene, 53676 Neighboring gene predicted gene, 51887

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38936

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    echinoderm microtubule-associated protein-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146016.2 → NP_666128.2  echinoderm microtubule-associated protein-like 6

      See identical proteins and their annotated locations for NP_666128.2

      Status: VALIDATED

      Source sequence(s)
      AK049034, AK081418, BB395696, BB633761, BC024726, BY740982
      UniProtKB/Swiss-Prot
      Q5SQM0, Q8C4R3, Q8C7L3, Q8R1E3
      Related
      ENSMUSP00000051080.6, ENSMUST00000058902.6
      Conserved Domains (4) summary
      COG2319
      Location:48 → 464
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29693044..29976044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156653.1 → XP_036012546.1  echinoderm microtubule-associated protein-like 6 isoform X1

      Conserved Domains (5) summary
      smart00320
      Location:1948 → 1987
      WD40; WD40 repeats
      COG2319
      Location:1433 → 1862
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_036156654.1 → XP_036012547.1  echinoderm microtubule-associated protein-like 6 isoform X6

      Conserved Domains (5) summary
      smart00320
      Location:1923 → 1962
      WD40; WD40 repeats
      COG2319
      Location:1408 → 1837
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_017314513.3 → XP_017170002.1  echinoderm microtubule-associated protein-like 6 isoform X2

      Conserved Domains (5) summary
      smart00320
      Location:1947 → 1986
      WD40; WD40 repeats
      COG2319
      Location:1432 → 1861
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_017314516.3 → XP_017170005.1  echinoderm microtubule-associated protein-like 6 isoform X5

      Conserved Domains (5) summary
      smart00320
      Location:1924 → 1963
      WD40; WD40 repeats
      COG2319
      Location:1409 → 1838
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_017314515.3 → XP_017170004.1  echinoderm microtubule-associated protein-like 6 isoform X4

      Conserved Domains (5) summary
      smart00320
      Location:1940 → 1979
      WD40; WD40 repeats
      COG2319
      Location:1425 → 1854
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_017314514.3 → XP_017170003.1  echinoderm microtubule-associated protein-like 6 isoform X3

      Conserved Domains (5) summary
      smart00320
      Location:1943 → 1982
      WD40; WD40 repeats
      COG2319
      Location:1428 → 1857
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_006514694.5 → XP_006514757.1  echinoderm microtubule-associated protein-like 6 isoform X1

      Conserved Domains (5) summary
      smart00320
      Location:1948 → 1987
      WD40; WD40 repeats
      COG2319
      Location:1433 → 1862
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:2 → 48
      HELP; HELP motif
      cl29593
      Location:57 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_006514695.4 → XP_006514758.1  echinoderm microtubule-associated protein-like 6 isoform X7

      Conserved Domains (5) summary
      smart00320
      Location:1155 → 1194
      WD40; WD40 repeats
      COG2319
      Location:640 → 1069
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:232 → 272
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:600 → 640
      HELP; HELP motif
      cl29593
      Location:224 → 497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001779999.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SQM0.1 GenPept UniProtKB/Swiss-Prot:Q5SQM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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