Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gga1provided by MGI
Official Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by MGI
Primary source: MGI:MGI:2146207
See related: Ensembl:ENSMUSG00000033128 AllianceGenome:MGI:2146207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930406E12Rik
Summary: Predicted to enable small GTPase binding activity. Involved in Golgi to plasma membrane transport and protein localization to ciliary membrane. Acts upstream of or within positive regulation of protein catabolic process. Predicted to be located in Golgi apparatus; early endosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in trans-Golgi network. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and white fat. Orthologous to human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 56.3), duodenum adult (RPKM 51.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78761069..78778785)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78877167..78894585)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 governing localization to the endosome compartment.
Title: GGA1 interacts with the endosomal Na+/H+ exchanger NHE6 governing localization to the endosome compartment.
GGA1 participates in spermatogenesis in mice under stress.
Title: GGA1 participates in spermatogenesis in mice under stress.
These results suggested that GGA1 plays a significant role in the formation and maturation of myotubes by targeting the insulin receptor to the cell surface to establish functionally mature myofibers.
Title: Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts.
novel protein complex composed of Rabep1, GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 andpolycystin 2 to the cilium.
Title: Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
GGA1 interacts with internal LRP9 and LRP12 DXXLL motifs.
Title: Do GGA adaptors bind internal DXXLL motifs?
depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury.
Title: Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Glut4 insulin-responsive trafficking is mediated by GGA adaptors in mouse adipocytes
Title: Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.
serine phosphorylation of BACE is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1
Title: Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP
Title: Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins.
the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles
Title: Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW209092 (e-PCR)
- UniSTS:180781

AU016030 (e-PCR)
- UniSTS:160475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to ciliary membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-ribosylation factor-binding protein GGA1

Names: gamma-adaptin-related protein 1; golgi-localized, gamma ear-containing, ARF-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145929.2 → NP_666041.1 ADP-ribosylation factor-binding protein GGA1

See identical proteins and their annotated locations for NP_666041.1

Status: VALIDATED

Source sequence(s)

AL592169

Consensus CDS

CCDS27625.1

UniProtKB/Swiss-Prot

Q3U2N1, Q8R0H9

Related

ENSMUSP00000035992.8, ENSMUST00000041587.8

Conserved Domains (5) summary

smart00809
Location:513 → 627

Alpha_adaptinC2; Adaptin C-terminal domain

cd03567
Location:9 → 147

VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...

cd14239
Location:210 → 298

GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2

pfam06674
Location:382 → 445

DUF1176; Protein of unknown function (DUF1176)

cl00753
Location:180 → 234

DUF327; Protein of unknown function (DUF327)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78761069..78778785

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316362.3 → XP_017171851.1 ADP-ribosylation factor-binding protein GGA1 isoform X1

Conserved Domains (5) summary

cd14239
Location:210 → 298

GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2

pfam05109
Location:314 → 517

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd17009
Location:9 → 147

VHS_GGA1; VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA1

pfam02883
Location:510 → 562

Alpha_adaptinC2; Adaptin C-terminal domain

pfam18308
Location:169 → 207

GGA_N-GAT; GGA N-GAT domain