Tollip toll interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tollipprovided by MGI
Official Full Name: toll interacting proteinprovided by MGI
Primary source: MGI:MGI:1891808
See related: Ensembl:ENSMUSG00000025139 AllianceGenome:MGI:1891808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930403G24Rik; 4931428G15Rik
Summary: Predicted to enable several functions, including enzyme binding activity; signaling receptor binding activity; and ubiquitin-like protein binding activity. Involved in interleukin-1-mediated signaling pathway. Part of protein-containing complex. Is expressed in ovary; renal interstitium; renal vasculature; and testis. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 75.3), cerebellum adult (RPKM 36.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141435317..141456198, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141881580..141902461, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
Title: TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
Title: Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
Title: BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
Title: Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
Title: TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
Title: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-kappaB signaling pathway.
Title: Protective effect of toll-interacting protein overexpression against paraquat-induced lung injury in mice and A549 cells through inhibiting oxidative stress, inflammation, and NF-κB signaling pathway.
Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
Title: Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.
TOLLIP decreases lung-specific TLR responses to increase susceptibility to Legionella pneumophila pneumonia.
Title: TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.
our findings reveal that resting-state STING protein level is strictly regulated by a constant tug-of-war between 'stabilizer' TOLLIP and 'degrader' IRE1alpha-lysosome that together maintain tissue immune homeostasis
Title: Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables Toll-like receptor binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-1, type I receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347562.1 → NP_001334491.1 toll-interacting protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL772165

Consensus CDS

CCDS85459.1

UniProtKB/TrEMBL

F7AT44, Q8BQL7

Related

ENSMUSP00000117938.3, ENSMUST00000130439.3

Conserved Domains (2) summary

cd04016
Location:48 → 168

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:226 → 266

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins
NM_023764.4 → NP_076253.1 toll-interacting protein isoform 1

See identical proteins and their annotated locations for NP_076253.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK016482, AL772165, CF171126

Consensus CDS

CCDS22020.1

UniProtKB/Swiss-Prot

Q543N1, Q9D5P5, Q9QZ06

UniProtKB/TrEMBL

Q8BQL7

Related

ENSMUSP00000001950.6, ENSMUST00000001950.12

Conserved Domains (2) summary

cd04016
Location:52 → 172

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:230 → 270

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins