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    Rdh1 retinol dehydrogenase 1 (all trans) [ Mus musculus (house mouse) ]

    Gene ID: 107605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rdh1provided by MGI
    Official Full Name
    retinol dehydrogenase 1 (all trans)provided by MGI
    Primary source
    MGI:MGI:1195275
    See related
    Ensembl:ENSMUSG00000089789 AllianceGenome:MGI:1195275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity and steroid dehydrogenase activity. Acts upstream of or within retinoid metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including Rathke's pouch; central nervous system; genitourinary system; liver; and lung. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 10.7), liver E18 (RPKM 2.1) and 4 other tissues See more
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    Genomic context

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    See Rdh1 in Genome Data Viewer
    Location:
    10 D3; 10 75.21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127595595..127604168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127759726..127768299)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_28236 Neighboring gene G protein-coupled receptor 182 Neighboring gene STARR-seq mESC enhancer starr_28237 Neighboring gene retinol dehydrogenase 9 Neighboring gene retinol dehydrogenase 16 Neighboring gene STARR-seq mESC enhancer starr_28238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1. Zhang M, et al. J Biol Chem, 2001 Nov 23. PMID 11562362
    2. RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Krois CR, et al. Cell Mol Life Sci, 2019 Jun. PMID 30788515, Free PMC Article
    3. Cloning and structural analysis of the murine GCN5L1 gene. Driessen CA, et al. Gene, 1997 Dec 5. PMID 9426003
    4. Gene structure and minimal promoter of mouse rdh1. Zhang M, et al. Gene, 2003 Feb 13. PMID 12594048
    5. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. Zhang M, et al. J Biol Chem, 2004 Dec 3. PMID 15355969

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rdh1-generated all-trans-retinoic acid in brown adipose tissue regulates multiple genes that promote brown adipose tissue adaptation to whole-body energy status, such as fasting and re-feeding.
      Title: RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding.
    2. Altered vitamin A homeostasis and increased size and adiposity is associated with rdh1-null mouse
      Title: Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse.
    3. Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm
      Title: Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 16
    Names
    retinol dehydrogenase 1 (11-cis)
    NP_536684.2
    XP_006513093.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080436.3 → NP_536684.2  retinol dehydrogenase 16 precursor

      See identical proteins and their annotated locations for NP_536684.2

      Status: VALIDATED

      Source sequence(s)
      AC129576, AK136574, AY028928
      Consensus CDS
      CCDS24250.1
      UniProtKB/TrEMBL
      Q8CGV4, Q8VIJ7
      Related
      ENSMUSP00000073322.6, ENSMUST00000073639.6
      Conserved Domains (2) summary
      cd09805
      Location:30 → 306
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:30 → 211
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127595595..127604168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513030.5 → XP_006513093.1  retinol dehydrogenase 16 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30 → 193
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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