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    Dlk2 delta like non-canonical Notch ligand 2 [ Mus musculus (house mouse) ]

    Gene ID: 106565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlk2provided by MGI
    Official Full Name
    delta like non-canonical Notch ligand 2provided by MGI
    Primary source
    MGI:MGI:2146838
    See related
    Ensembl:ENSMUSG00000047428 AllianceGenome:MGI:2146838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLK-2; Egfl9
    Summary
    Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 29.8), frontal lobe adult (RPKM 21.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dlk2 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46608342..46614197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46297256..46303271)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene tight junction associated protein 1 Neighboring gene predicted gene, 41588 Neighboring gene ATP-binding cassette, sub-family C member 10 Neighboring gene STARR-positive B cell enhancer ABC_E1943 Neighboring gene cDNA sequence BC040756 Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Delta-like 2 negatively regulates chondrogenic differentiation. Xu W, et al. J Cell Physiol, 2018 Sep. PMID 29057471
    2. Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam. Navarrete F, et al. Psychoneuroendocrinology, 2017 Nov. PMID 28863347
    3. Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis. Garcia-Gallastegi P, et al. Histochem Cell Biol, 2019 Jul. PMID 30888503
    4. Characterization of a proximal Sp1 response element in the mouse Dlk2 gene promoter. Rivero S, et al. BMC Mol Biol, 2011 Dec 20. PMID 22185379, Free PMC Article
    5. Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation. Chen X, et al. Cell Death Dis, 2023 Sep 5. PMID 37669921, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
      Title: Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
    2. The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5.
      Title: Delta-like 2 negatively regulates chondrogenic differentiation.
    3. The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation.
      Title: Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.
    4. Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress.
      Title: Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam.
    5. KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis
      Title: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis.
    6. Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription
      Title: Characterization of a proximal Sp1 response element in the mouse Dlk2 gene promoter.
    7. Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling.
      Title: The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.
    8. Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2.
      Title: The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein delta homolog 2
    Names
    EGF-like protein 9
    EGF-like-domain, multiple 9
    delta-like 2 homolog
    endothelial cell-specific protein S-1
    epidermal growth factor-like protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286013.2 → NP_001272942.1  protein delta homolog 2 precursor

      See identical proteins and their annotated locations for NP_001272942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009572
      Consensus CDS
      CCDS37634.2
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
      Related
      ENSMUSP00000128897.2, ENSMUST00000166617.8
      Conserved Domains (1) summary
      cd00054
      Location:174 → 210
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. NM_001286028.2 → NP_001272957.1  protein delta homolog 2 precursor

      See identical proteins and their annotated locations for NP_001272957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT009572
      Consensus CDS
      CCDS37634.2
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
      Related
      ENSMUSP00000126993.2, ENSMUST00000166280.8
      Conserved Domains (1) summary
      cd00054
      Location:174 → 210
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. NM_001414441.1 → NP_001401370.1  protein delta homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009572
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

    4. NM_001414442.1 → NP_001401371.1  protein delta homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009572
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

    5. NM_001414443.1 → NP_001401372.1  protein delta homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009572
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
      Related
      ENSMUSP00000058470.7, ENSMUST00000061722.13

    6. NM_001414444.1 → NP_001401373.1  protein delta homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT009572
      UniProtKB/Swiss-Prot
      B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46608342..46614197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134120.2: Suppressed sequence

      Description
      NM_134120.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_207666.2: Suppressed sequence

      Description
      NM_207666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1E3.3 GenPept UniProtKB/Swiss-Prot:Q8K1E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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