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    Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 104681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc16a6provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 6provided by MGI
    Primary source
    MGI:MGI:2144585
    See related
    Ensembl:ENSMUSG00000041920 AllianceGenome:MGI:2144585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT6; MCT 6; MCT 7; ESTM12
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; integumental system; liver; retina; and urinary system. Orthologous to human SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 4.3), liver E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc16a6 in Genome Data Viewer
    Location:
    11 E1; 11 71.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109341681..109366428, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109450855..109473598, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7086 Neighboring gene STARR-positive B cell enhancer ABC_E5291 Neighboring gene predicted gene 11696 Neighboring gene guanine nucleotide binding protein, alpha 13 Neighboring gene STARR-positive B cell enhancer ABC_E4009 Neighboring gene STARR-positive B cell enhancer ABC_E7087 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109281499-109281800 Neighboring gene STARR-positive B cell enhancer ABC_E380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109287298-109287521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109293875-109294028 Neighboring gene STARR-positive B cell enhancer ABC_E10727 Neighboring gene STARR-positive B cell enhancer ABC_E5293 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene predicted gene, 45916 Neighboring gene STARR-positive B cell enhancer ABC_E5294 Neighboring gene STARR-positive B cell enhancer ABC_E7088 Neighboring gene STARR-positive B cell enhancer ABC_E1846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109357315-109357468 Neighboring gene arylsulfatase G Neighboring gene predicted gene, 22378 Neighboring gene STARR-positive B cell enhancer ABC_E7089 Neighboring gene predicted gene, 39442 Neighboring gene WD repeat domain, phosphoinositide interacting 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Jones RS, et al. Mol Pharmacol, 2019 Sep. PMID 31436537, Free PMC Article
    2. Functional analysis of candidate genes from genome-wide association studies of hearing. Ingham NJ, et al. Hear Res, 2020 Mar 1. PMID 31927188, Free PMC Article
    3. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results from the knockout (KO) mouse model of Mct6 deficiency support the importance of MCT6 in regulating a variety of glucose and lipid metabolic pathways, which may indicate its significance in metabolic diseases.
      Title: Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27628

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables taurine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in taurine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 7
    Names
    monocarboxylate transporter 6
    solute carrier family 16 member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029842.3 → NP_001025013.2  monocarboxylate transporter 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL645791
      Consensus CDS
      CCDS25580.1
      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Related
      ENSMUSP00000065628.6, ENSMUST00000070152.12

    2. NM_001363364.2 → NP_001350293.1  monocarboxylate transporter 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645791
      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Conserved Domains (1) summary
      cd17422
      Location:40 → 488
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    3. NM_134038.4 → NP_598799.1  monocarboxylate transporter 7 isoform b

      See identical proteins and their annotated locations for NP_598799.1

      Status: VALIDATED

      Source sequence(s)
      AL645791
      Consensus CDS
      CCDS36360.1
      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Related
      ENSMUSP00000067423.7, ENSMUST00000070872.13
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109341681..109366428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156212.1 → XP_036012105.1  monocarboxylate transporter 7 isoform X4

      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Conserved Domains (1) summary
      cl28910
      Location:108 → 465
      MFS; Major Facilitator Superfamily

    2. XM_036156210.1 → XP_036012103.1  monocarboxylate transporter 7 isoform X1

      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Conserved Domains (1) summary
      cd17422
      Location:108 → 508
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    3. XM_017314216.3 → XP_017169705.1  monocarboxylate transporter 7 isoform X2

      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Conserved Domains (1) summary
      cd17422
      Location:40 → 488
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    4. XM_036156214.1 → XP_036012107.1  monocarboxylate transporter 7 isoform X5

      Conserved Domains (1) summary
      cd17422
      Location:24 → 424
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    5. XM_036156211.1 → XP_036012104.1  monocarboxylate transporter 7 isoform X3

      UniProtKB/Swiss-Prot
      B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
      Conserved Domains (1) summary
      cd17422
      Location:24 → 472
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

    6. XM_036156213.1 → XP_036012106.1  monocarboxylate transporter 7 isoform X5

      Conserved Domains (1) summary
      cd17422
      Location:24 → 424
      MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AT66.1 GenPept UniProtKB/Swiss-Prot:B1AT66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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