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    Cnih2 cornichon family AMPA receptor auxiliary protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 12794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnih2provided by MGI
    Official Full Name
    cornichon family AMPA receptor auxiliary protein 2provided by MGI
    Primary source
    MGI:MGI:1277225
    See related
    Ensembl:ENSMUSG00000024873 AllianceGenome:MGI:1277225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnil; CNIH-2
    Summary
    This gene encodes a protein that is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. This protein is similar to a Drosophila protein involved in anterior-posterior and dorsal-ventral patterning. Cnih2 conditional knockout mice exhibit reduced AMPA receptor synaptic transmission in the hippocampus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in CNS E18 (RPKM 138.4), whole brain E14.5 (RPKM 130.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnih2 in Genome Data Viewer
    Location:
    19 A; 19 4.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5142896..5148549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5092868..5098521, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1968 Neighboring gene uncharacterized LOC132660285 Neighboring gene CD248 antigen, endosialin Neighboring gene STARR-positive B cell enhancer ABC_E7627 Neighboring gene transmembrane protein 151A Neighboring gene Yip1 interacting factor homolog A (S. cerevisiae) Neighboring gene RAB1B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E1969 Neighboring gene kinesin light chain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits. Straub C, et al. Curr Opin Neurobiol, 2012 Jun. PMID 21993243, Free PMC Article
    2. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. Schober DA, et al. J Biol Chem, 2011 Apr 15. PMID 21343286, Free PMC Article
    3. Gating and modulation of a hetero-octameric AMPA glutamate receptor. Zhang D, et al. Nature, 2021 Jun. PMID 34079129, Free PMC Article
    4. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. Gill MB, et al. J Neurosci, 2011 May 4. PMID 21543622, Free PMC Article
    5. The mouse cornichon gene family. Hwang SY, et al. Dev Genes Evol, 1999 Feb. PMID 10022955

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gating and modulation of a hetero-octameric AMPA glutamate receptor.
      Title: Gating and modulation of a hetero-octameric AMPA glutamate receptor.
    2. Cornichon-2 and cornichon-3 dictate subunit-specific AMPA receptor trafficking and synaptic transmission.
      Title: Cornichon proteins determine the subunit composition of synaptic AMPA receptors.
    3. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.
      Title: Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.
    4. Cornichon homolog 2 (CNIH-2) associates with TARP gamma-8 in hippocampus postsynaptic densities; CNIH-2 protein levels are diminished in transmembrane AMPA receptor regulatory protein (TARP) gamma-8 knockout mice.
      Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118475

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within localization within membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein cornichon homolog 2
    Names
    cornichon homolog 2
    cornichon-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302333.1 → NP_001289262.1  protein cornichon homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001289262.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC124502, AK141483, CX243776
      UniProtKB/TrEMBL
      Q3SYI8
      Conserved Domains (1) summary
      pfam03311
      Location:19 → 106
      Cornichon; Cornichon protein

    2. NM_009920.4 → NP_034050.1  protein cornichon homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_034050.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141483, CX243776
      Consensus CDS
      CCDS29451.1
      UniProtKB/Swiss-Prot
      O35089
      UniProtKB/TrEMBL
      Q3SYI8
      Related
      ENSMUSP00000025805.7, ENSMUST00000025805.8
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 151
      Cornichon; Cornichon protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5142896..5148549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35089.2 GenPept UniProtKB/Swiss-Prot:O35089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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