Arhgap27 Rho GTPase activating protein 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap27provided by MGI
Official Full Name: Rho GTPase activating protein 27provided by MGI
Primary source: MGI:MGI:1916903
See related: Ensembl:ENSMUSG00000034255 AllianceGenome:MGI:1916903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sh3d20; Gm21552; 2310069I04Rik; 5730442P18Rik
Summary: Predicted to enable GTPase activator activity and SH3 domain binding activity. Predicted to be involved in Rho protein signal transduction and receptor-mediated endocytosis. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; sensory organ; and skeleton. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 40.0), duodenum adult (RPKM 33.5) and 18 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11; 11 E1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103222310..103254518, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103331484..103363692, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:495720

NoName (e-PCR)
- UniSTS:490646

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: rho GTPase-activating protein 27

Names: CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; SH3 domain containing 20; rho-type GTPase-activating protein 27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205236.1 → NP_001192165.1 rho GTPase-activating protein 27 isoform 1

See identical proteins and their annotated locations for NP_001192165.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL662804, AL772325

Consensus CDS

CCDS56815.1

UniProtKB/Swiss-Prot

A2AB59, Q3V366, Q4V9V5

Related

ENSMUSP00000102639.2, ENSMUST00000107024.9

Conserved Domains (6) summary

cd12069
Location:10 → 66

SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

COG5104
Location:241 → 328

PRP40; Splicing factor [RNA processing and modification]

PRK12323
Location:68 → 249

PRK12323; DNA polymerase III subunit gamma/tau

cd04403
Location:675 → 861

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:480 → 594

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:248 → 278

WW; WW domain
NM_133715.5 → NP_598476.2 rho GTPase-activating protein 27 isoform 2

See identical proteins and their annotated locations for NP_598476.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate internal promoter, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK046763, AL662804, BY552449

Consensus CDS

CCDS25517.1

UniProtKB/Swiss-Prot

A2AB59

Related

ENSMUSP00000039427.8, ENSMUST00000041385.14

Conserved Domains (4) summary

cd04403
Location:476 → 662

RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...

cd13233
Location:281 → 395

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:281 → 394

PH; PH domain

pfam00397
Location:49 → 79

WW; WW domain
NM_183288.3 → NP_899111.2 rho GTPase-activating protein 27 isoform 3

See identical proteins and their annotated locations for NP_899111.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several 3' exons and contains an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is significantly shorter than isoform 1.

Source sequence(s)

AL772325, CJ068176

Consensus CDS

CCDS36350.1

UniProtKB/TrEMBL

A2AKN5, B2RR95

Related

ENSMUSP00000102637.3, ENSMUST00000092557.6

Conserved Domains (1) summary

cd12069
Location:10 → 66

SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

103222310..103254518 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156858.1 → XP_036012751.1 rho GTPase-activating protein 27 isoform X3

Conserved Domains (6) summary

cd12069
Location:10 → 66

SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

COG5104
Location:241 → 328

PRP40; Splicing factor [RNA processing and modification]

PRK12323
Location:68 → 249

PRK12323; DNA polymerase III subunit gamma/tau

cd04403
Location:620 → 806

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:425 → 539

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:248 → 278

WW; WW domain
XM_036156857.1 → XP_036012750.1 rho GTPase-activating protein 27 isoform X2

Conserved Domains (6) summary

cd12069
Location:10 → 66

SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

COG5104
Location:241 → 328

PRP40; Splicing factor [RNA processing and modification]

PRK12323
Location:68 → 249

PRK12323; DNA polymerase III subunit gamma/tau

cd04403
Location:647 → 833

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:452 → 566

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:248 → 278

WW; WW domain
XM_036156856.1 → XP_036012749.1 rho GTPase-activating protein 27 isoform X1

UniProtKB/Swiss-Prot

A2AB59, Q3V366, Q4V9V5

Conserved Domains (6) summary

cd12069
Location:10 → 66

SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

COG5104
Location:241 → 328

PRP40; Splicing factor [RNA processing and modification]

PRK12323
Location:68 → 249

PRK12323; DNA polymerase III subunit gamma/tau

cd04403
Location:675 → 861

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:480 → 594

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:248 → 278

WW; WW domain
XM_006533754.5 → XP_006533817.1 rho GTPase-activating protein 27 isoform X4

Conserved Domains (4) summary

COG5104
Location:56 → 143

PRP40; Splicing factor [RNA processing and modification]

cd04403
Location:490 → 676

RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

cd13233
Location:295 → 409

PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

pfam00397
Location:63 → 93

WW; WW domain