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    Srsf1 serine and arginine-rich splicing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 110809, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srsf1provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 1provided by MGI
    Primary source
    MGI:MGI:98283
    See related
    Ensembl:ENSMUSG00000018379 AllianceGenome:MGI:98283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 77.9), CNS E14 (RPKM 62.5) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srsf1 in Genome Data Viewer
    Location:
    11 C; 11 52.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87937325..87944583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88046499..88053757)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610 Neighboring gene STARR-positive B cell enhancer ABC_E9835 Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA topoisomerase binding  
    enables RNA binding  
    enables RNA binding  
    enables RS domain binding PubMed 
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables mRNA binding PubMed 
    enables molecular function regulator activity PubMed 
    enables protein binding PubMed 
    enables protein kinase B binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing PubMed 
    acts_upstream_of_or_within RNA splicing PubMed 
    involved_in alternative mRNA splicing, via spliceosome  
    involved_in alternative mRNA splicing, via spliceosome  
    acts_upstream_of_or_within cardiac muscle contraction PubMed 
    involved_in cellular response to interleukin-17 PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in interleukin-17-mediated signaling pathway PubMed 
    involved_in interleukin-17-mediated signaling pathway PubMed 
    involved_in mRNA 5'-splice site recognition  
    involved_in mRNA 5'-splice site recognition  
    involved_in mRNA stabilization PubMed 
    involved_in mRNA stabilization PubMed 
    involved_in mRNA transport  
    involved_in positive regulation of RNA splicing  
    involved_in protein localization to P-body PubMed 
    involved_in protein localization to nucleus PubMed 
    involved_in regulation of RNA splicing PubMed 
    involved_in signal transduction involved in regulation of gene expression PubMed 
    involved_in signal transduction involved in regulation of gene expression PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of exon-exon junction complex  
    located_in nuclear envelope  
    is_active_in nuclear speck  
    located_in nuclear speck PubMed 
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of spliceosomal complex  

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 1
    Names
    ASF/SF2
    pre-mRNA-splicing factor SRp30a
    splicing factor, arginine/serine-rich 1 (ASF/SF2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078167.2NP_001071635.1  serine/arginine-rich splicing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001071635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK053674, AK078715, AL593853, CF739274
      Consensus CDS
      CCDS36274.1
      UniProtKB/Swiss-Prot
      Q6PDM2
      Related
      ENSMUSP00000133517.2, ENSMUST00000079866.11
      Conserved Domains (3) summary
      COG0724
      Location:888
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12597
      Location:1790
      RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cl17169
      Location:121190
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_173374.4NP_775550.2  serine/arginine-rich splicing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_775550.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK053674, AL593853, CF739274
      Consensus CDS
      CCDS36273.1
      UniProtKB/Swiss-Prot
      B2KGJ5, Q3UCH2, Q5SXC5, Q6PDM2, Q8BJV3, Q8C1H9
      Related
      ENSMUSP00000120595.3, ENSMUST00000139129.9
      Conserved Domains (2) summary
      cd12597
      Location:1290
      RRM1_SRSF1; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cd12767
      Location:113196
      RRM2_SRSF1; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87937325..87944583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388324.4 RNA Sequence

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