U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AK-HSDH II aspartate kinase-homoserine dehydrogenase ii [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827715, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AK-HSDH II
    Official Full Name
    aspartate kinase-homoserine dehydrogenase ii
    Primary source
    TAIR:AT4G19710
    Locus tag
    AT4G19710
    See related
    Araport:AT4G19710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AK-HSDH; ASPARTATE KINASE-HOMOSERINE DEHYDROGENASE; aspartate kinase-homoserine dehydrogenase ii; T16H5.70; T16H5_70
    Summary
    Encodes a bifunctional aspartate kinase/homoserine dehydrogenase. These two activities catalyze the first and the third steps toward the synthesis of the essential amino acids threonine, isoleucine and methionine.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AK-HSDH II in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (10724814..10729768)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SBP (S-ribonuclease binding protein) family protein Neighboring gene Glycosyl hydrolase family protein with chitinase insertion domain-containing protein Neighboring gene Glycosyl hydrolase superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity. Curien G, et al. J Biol Chem, 2005 Dec 16. PMID 16216875
    2. Molecular analysis of the aspartate kinase-homoserine dehydrogenase gene from Arabidopsis thaliana. Ghislain M, et al. Plant Mol Biol, 1994 Mar. PMID 8204822
    3. Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents. Clark TJ, et al. Plant Physiol, 2015 Aug. PMID 26063505, Free PMC Article
    4. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that mutations in the Asp kinases (AKs) and dual-functional Asp kinase-homoserine dehydrogenases (AK-HSDHs) result in reduced transcript levels and gene product activitiee and increases in the contents of Asp-derived amino acids.
      Title: Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_118091.3
    NM_202847.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homoserine dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aspartate family amino acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in homoserine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via diaminopimelate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methionine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    aspartate kinase-homoserine dehydrogenase ii
    NP_193706.2
    • aspartate kinase-homoserine dehydrogenase ii (AK-HSDH II); FUNCTIONS IN: homoserine dehydrogenase activity, aspartate kinase activity; INVOLVED IN: aspartate family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Homoserine dehydrogenase, catalytic (InterPro:IPR001342), Amino acid-binding ACT (InterPro:IPR002912), Aspartate/homoserine dehydrogenase, NAD-binding (InterPro:IPR005106), Aspartate kinase, conserved site (InterPro:IPR018042), Bifunctional aspartokinase/homoserine dehydrogenase I (InterPro:IPR011147), Aspartate kinase domain (InterPro:IPR001341), NAD(P)-binding domain (InterPro:IPR016040), Homoserine dehydrogenase, conserved site (InterPro:IPR019811); BEST Arabidopsis thaliana protein match is: aspartate kinase-homoserine dehydrogenase i (TAIR:AT1G31230.1); Has 17435 Blast hits to 17108 proteins in 2575 species: Archae - 421; Bacteria - 11654; Metazoa - 7; Fungi - 299; Plants - 259; Viruses - 0; Other Eukaryotes - 4795 (source: NCBI BLink).
    NP_974576.1
    • aspartate kinase-homoserine dehydrogenase ii (AK-HSDH II); FUNCTIONS IN: homoserine dehydrogenase activity, aspartate kinase activity; INVOLVED IN: aspartate family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Homoserine dehydrogenase, catalytic (InterPro:IPR001342), Amino acid-binding ACT (InterPro:IPR002912), Aspartate/homoserine dehydrogenase, NAD-binding (InterPro:IPR005106), Aspartate kinase, conserved site (InterPro:IPR018042), NAD(P)-binding domain (InterPro:IPR016040), Aspartate kinase domain (InterPro:IPR001341), Bifunctional aspartokinase/homoserine dehydrogenase I (InterPro:IPR011147), Homoserine dehydrogenase, conserved site (InterPro:IPR019811); BEST Arabidopsis thaliana protein match is: aspartate kinase-homoserine dehydrogenase i (TAIR:AT1G31230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10724814..10729768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202847.3 → NP_974576.1  aspartate kinase-homoserine dehydrogenase ii [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81852, Q3E9Y8
      UniProtKB/TrEMBL
      A0A178V4Q7, A0A654FQY0, Q0WRP9
      Conserved Domains (1) summary
      PRK09436
      Location:89 → 914
      thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional

    2. NM_118091.3 → NP_193706.2  aspartate kinase-homoserine dehydrogenase ii [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193706.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V4Q7
      Conserved Domains (6) summary
      cd04921
      Location:407 → 486
      ACT_AKi-HSDH-ThrA-like_1; ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH)
      cd04922
      Location:488 → 553
      ACT_AKi-HSDH-ThrA_2; ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH)
      PRK09436
      Location:89 → 836
      thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
      cd04257
      Location:89 → 383
      AAK_AK-HSDH; AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli ...
      pfam00742
      Location:716 → 827
      Homoserine_dh; Homoserine dehydrogenase
      pfam03447
      Location:564 → 700
      NAD_binding_3; Homoserine dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81852.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.