Rarres2 retinoic acid receptor responder (tazarotene induced) 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rarres2provided by MGI
Official Full Name: retinoic acid receptor responder (tazarotene induced) 2provided by MGI
Primary source: MGI:MGI:1918910
See related: Ensembl:ENSMUSG00000009281 AllianceGenome:MGI:1918910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610007L05Rik
Summary: Predicted to enable signaling receptor binding activity. Involved in several processes, including positive regulation of fat cell differentiation; positive regulation of protein phosphorylation; and regulation of insulin receptor signaling pathway. Acts upstream of or within brown fat cell differentiation. Located in extracellular region. Is expressed in genitourinary system; jaw; and retina. Orthologous to human RARRES2 (retinoic acid receptor responder 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 313.8), placenta adult (RPKM 166.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 23.55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48546630..48549778, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48569696..48572845, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
Title: The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
Title: Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
Title: Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin.
Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
Title: Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins.
Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
Title: RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.
Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
Title: Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
Title: Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia.
The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoic acid receptor responder protein 2

Names: chemerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347167.1 → NP_001334096.1 retinoic acid receptor responder protein 2 isoform 1 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC154013

Consensus CDS

CCDS85040.1

UniProtKB/TrEMBL

A0A0N4SVV4

Related

ENSMUSP00000009425.6, ENSMUST00000009425.7

Conserved Domains (1) summary

cl29764
Location:65 → 108

Cathelicidins
NM_001347168.1 → NP_001334097.1 retinoic acid receptor responder protein 2 isoform 2 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).

Source sequence(s)

AC154013

Consensus CDS

CCDS20105.1

UniProtKB/Swiss-Prot

Q8CHU8, Q9DD06

Related

ENSMUSP00000144799.2, ENSMUST00000204930.3

Conserved Domains (1) summary

pfam00666
Location:65 → 108

Cathelicidins; Cathelicidin
NM_027852.3 → NP_082128.1 retinoic acid receptor responder protein 2 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_082128.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encodes the protein (isoform 2).

Source sequence(s)

AC154013

Consensus CDS

CCDS20105.1

UniProtKB/Swiss-Prot

Q8CHU8, Q9DD06

Related

ENSMUSP00000144793.2, ENSMUST00000204267.3

Conserved Domains (1) summary

pfam00666
Location:65 → 108

Cathelicidins; Cathelicidin