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    Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator [ Mus musculus (house mouse) ]

    Gene ID: 74490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mamstrprovided by MGI
    Official Full Name
    MEF2 activating motif and SAP domain containing transcriptional regulatorprovided by MGI
    Primary source
    MGI:MGI:1921740
    See related
    Ensembl:ENSMUSG00000042918 AllianceGenome:MGI:1921740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mastr; 2810022D01Rik; 5430432N15Rik
    Summary
    Predicted to enable transcription coregulator activity. Acts upstream of or within positive regulation of myotube differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human MAMSTR (MEF2 activating motif and SAP domain containing transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 3.5), mammary gland adult (RPKM 1.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mamstr in Genome Data Viewer
    Location:
    7 B3; 7 29.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45288616..45297631)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45639192..45648207)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 1 Neighboring gene izumo sperm-egg fusion 1 Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression. Meadows SM, et al. Proc Natl Acad Sci U S A, 2008 Feb 5. PMID 18230740, Free PMC Article
    2. Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD. Yanay N, et al. Hum Mol Genet, 2019 Oct 15. PMID 31348492
    3. MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Mokalled MH, et al. Genes Dev, 2012 Jan 15. PMID 22279050, Free PMC Article
    4. Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Creemers EE, et al. Mol Cell, 2006 Jul 7. PMID 16818234
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD
      Title: Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of myotube differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MEF2-activating motif and SAP domain-containing transcriptional regulator
    Names
    MEF2-activating SAP transcriptional regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172418.2 → NP_766006.2  MEF2-activating motif and SAP domain-containing transcriptional regulator

      See identical proteins and their annotated locations for NP_766006.2

      Status: VALIDATED

      Source sequence(s)
      AC149057, BY137380, BY145171, BY717195
      Consensus CDS
      CCDS21257.2
      UniProtKB/Swiss-Prot
      A1L0X1, E9QM68, Q0ZCJ7, Q3B818
      Related
      ENSMUSP00000114686.2, ENSMUST00000148532.4
      Conserved Domains (1) summary
      pfam02037
      Location:168 → 194
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45288616..45297631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541232.3 → XP_006541295.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X1

      See identical proteins and their annotated locations for XP_006541295.1

      Conserved Domains (1) summary
      pfam02037
      Location:168 → 194
      SAP; SAP domain

    2. XM_006541234.3 → XP_006541297.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X2

      See identical proteins and their annotated locations for XP_006541297.1

      UniProtKB/Swiss-Prot
      A1L0X1, E9QM68, Q0ZCJ7, Q3B818
      Conserved Domains (1) summary
      pfam02037
      Location:168 → 194
      SAP; SAP domain

    3. XM_006541233.3 → XP_006541296.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X1

      See identical proteins and their annotated locations for XP_006541296.1

      Conserved Domains (1) summary
      pfam02037
      Location:168 → 194
      SAP; SAP domain

    4. XM_006541235.2 → XP_006541298.1  MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X3

      Conserved Domains (1) summary
      pfam02037
      Location:66 → 92
      SAP; SAP domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001146704.1: Suppressed sequence

      Description
      NM_001146704.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0ZCJ7.2 GenPept UniProtKB/Swiss-Prot:Q0ZCJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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