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    5'-3' exonuclease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832721, updated on 18-Sep-2024

    Summary

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    Official Full Name
    5'-3' exonuclease family protein
    Primary source
    TAIR:AT5G26680
    Locus tag
    AT5G26680
    See related
    Araport:AT5G26680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (9311446..9315550, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal hydrolase-like protein Neighboring gene Glutamyl/glutaminyl-tRNA synthetase, class Ic Neighboring gene RmlC-like cupins superfamily protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Pectinacetylesterase family protein Neighboring gene myb domain protein 86

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis. Zhang J, et al. Plant J, 2016 Sep. PMID 27231839, Free PMC Article
    2. Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development. Zhang Y, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26721386, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At5g26680 role in mediating transcriptional gene silencing as well as maintaining genome stability
      Title: Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.
    2. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.
      Title: Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001161268.2
    NM_001343976.1
    NM_001343977.1
    NM_001343978.1
    NM_180546.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to UV IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    5'-3' exonuclease family protein
    NP_001154740.1
    • 5'-3' exonuclease family protein; FUNCTIONS IN: 5'-3' exonuclease activity, DNA binding, catalytic activity, nuclease activity; INVOLVED IN: DNA repair; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: XPG conserved site (InterPro:IPR019974), XPG N-terminal (InterPro:IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro:IPR006084), 5'-3' exonuclease, N-terminal (InterPro:IPR002421), 5'-3' exonuclease, C-terminal subdomain (InterPro:IPR020045), Helix-hairpin-helix motif, class 2 (InterPro:IPR008918), XPG/RAD2 endonuclease (InterPro:IPR006086); BEST Arabidopsis thaliana protein match is: 5'-3' exonuclease family protein (TAIR:AT1G29630.2); Has 3563 Blast hits to 3243 proteins in 839 species: Archae - 284; Bacteria - 855; Metazoa - 643; Fungi - 727; Plants - 266; Viruses - 42; Other Eukaryotes - 746 (source: NCBI BLink).
    NP_850877.2
    • 5'-3' exonuclease family protein; FUNCTIONS IN: 5'-3' exonuclease activity, DNA binding, catalytic activity, nuclease activity; INVOLVED IN: DNA repair; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: XPG conserved site (InterPro:IPR019974), XPG N-terminal (InterPro:IPR006085), DNA repair protein (XPGC)/yeast Rad (InterPro:IPR006084), 5'-3' exonuclease, C-terminal subdomain (InterPro:IPR020045), 5'-3' exonuclease, N-terminal (InterPro:IPR002421), Helix-hairpin-helix motif, class 2 (InterPro:IPR008918), XPG/RAD2 endonuclease (InterPro:IPR006086); BEST Arabidopsis thaliana protein match is: 5'-3' exonuclease family protein (TAIR:AT1G29630.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9311446..9315550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161268.2 → NP_001154740.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154740.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65251
      UniProtKB/TrEMBL
      A0A7G2FGQ6
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 383
      PTZ00217; flap endonuclease-1; Provisional

    2. NM_001343978.1 → NP_001332058.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    3. NM_001343977.1 → NP_001332057.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    4. NM_001343976.1 → NP_001332056.1  5'-3' exonuclease family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UK25, A0A1P8BFQ5, A0A384KCK0, A0A7G2FA98
      Conserved Domains (1) summary
      PTZ00217
      Location:1 → 362
      PTZ00217; flap endonuclease-1; Provisional

    5. NM_180546.3 → NP_850877.2  5'-3' exonuclease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850877.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FGQ6, F4K191
      Conserved Domains (3) summary
      cd09907
      Location:222 → 290
      H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
      cd09867
      Location:4 → 346
      PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      PTZ00217
      Location:1 → 359
      PTZ00217; flap endonuclease-1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65251.2

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