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    PI-4KBETA1 phosphatidylinositol 4-OH kinase beta1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836528, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PI-4KBETA1
    Official Full Name
    phosphatidylinositol 4-OH kinase beta1
    Primary source
    TAIR:AT5G64070
    Locus tag
    AT5G64070
    See related
    Araport:AT5G64070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MHJ24.5; MHJ24_5; phosphatidylinositol 4-OH kinase beta1; PHOSPHATIDYLINOSITOL 4-OH KINASE BETA1; PI4KBETA1
    Summary
    Encodes a phosphatidylinositol 4-OH kinase, PI-4Kbeta1. Arabidopsis contains 12 PI-4Ks in three separate families: PI-4Kalphs, PI-4kbeta, and PI-4Kgamma. PI-4Kbeta1 is 83% identical to PI-4kbeta2 encoded by At5g09350. Interacts with the RabA4b GTPase. Important for polarized root hair growth as the loss of this gene and its close relative PI-4kbeta2, leads to the formation of abnormal root hairs.
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    Genomic context

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    See PI-4KBETA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (25636882..25644478, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glutamate tRNA synthetase Neighboring gene NAC domain containing protein 103 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene hyccin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The highly charged region of plant beta-type phosphatidylinositol 4-kinase is involved in membrane targeting and phospholipid binding. Lou Y, et al. Plant Mol Biol, 2006 Mar. PMID 16649109
    2. A plant 126-kDa phosphatidylinositol 4-kinase with a novel repeat structure. Cloning and functional expression in baculovirus-infected insect cells. Xue HW, et al. J Biol Chem, 1999 Feb 26. PMID 10026194
    3. PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole. Rubilar-Hernández C, et al. Plant Physiol, 2019 Sep. PMID 31285293, Free PMC Article
    4. A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis. Lin F, et al. EMBO J, 2019 Feb 15. PMID 30617084, Free PMC Article
    5. The Arabidopsis pi4kIIIβ1β2 double mutant is salicylic acid-overaccumulating: a new example of salicylic acid influence on plant stature. Janda M, et al. Plant Signal Behav, 2014. PMID 25482755, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
      Title: Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
    2. PI4KIIIbeta Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
      Title: PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
    3. PI4Kbeta1 and PI4Kbeta2 regulate microtubule dynamics in Arabidopsis in both cytokinetic and interphase root cells. [pi4kbeta1]
      Title: A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis.
    4. pi4kIIIbeta1beta2 double mutant stunted rosette is due to high salicylic acid, while the short root length is not.
      Title: The Arabidopsis pi4kIIIβ1β2 double mutant is salicylic acid-overaccumulating: a new example of salicylic acid influence on plant stature.
    5. PI4KIIIbeta1 and PI4KIIIbeta2 are genetically upstream of EDS1 and need functional salicylic acid biosynthesis and perception through NPR1 to express the dwarf phenotype. [PI4KIIIbeta1]
      Title: Constitutive salicylic acid accumulation in pi4kIIIβ1β2 Arabidopsis plants stunts rosette but not root growth.
    6. AtPI4KIIIbeta1 and AtPI4KIIIbeta2 can both act upstream of the PI-PLC.
      Title: Arabidopsis type-III phosphatidylinositol 4-kinases β1 and β2 are upstream of the phospholipase C pathway triggered by cold exposure.
    7. RabA4b and PI-4Kbeta1 localize to budding secretory vesicles (SVs) in the trans Golgi network and to SVs en route to the cell surface.
      Title: Electron tomography of RabA4b- and PI-4Kβ1-labeled trans Golgi network compartments in Arabidopsis.
    8. PI-4Kbeta1 interacts with RabA4b through a novel homology domain, and interacts with a Ca2+ sensor through its NH2 terminus.
      Title: A role for the RabA4b effector protein PI-4Kbeta1 in polarized expansion of root hair cells in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001345618.1
    NM_125803.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell tip growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in root hair tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-OH kinase beta1
    NP_201212.1
    • phosphatidylinositol 4-OH kinase beta1 (PI-4KBETA1); FUNCTIONS IN: 1-phosphatidylinositol 4-kinase activity; INVOLVED IN: phosphoinositide biosynthetic process, root hair cell tip growth, pollen tube growth; LOCATED IN: cytosol, nucleus, membrane; EXPRESSED IN: male gametophyte, root hair tip, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), Phosphatidylinositol Kinase (InterPro:IPR015433), Armadillo-type fold (InterPro:IPR016024), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: phosphatidylinositol 4-OH kinase beta2 (TAIR:AT5G09350.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25636882..25644478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125803.4 → NP_201212.1  phosphatidylinositol 4-OH kinase beta1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FMJ0, Q9ZPE1
      UniProtKB/TrEMBL
      A0A178U8R0
      Conserved Domains (2) summary
      pfam05793
      Location:230 → 540
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      cd05168
      Location:831 → 1121
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    2. NM_001345618.1 → NP_001330874.1  phosphatidylinositol 4-OH kinase beta1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BC59
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FMJ0.1

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