U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dihydrolipoamide acetyltransferase, long form protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841863, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    Dihydrolipoamide acetyltransferase, long form protein
    Primary source
    TAIR:AT1G54220
    Locus tag
    AT1G54220
    See related
    Araport:AT1G54220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20D21.4; F20D21_4
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (20246026..20250345, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene Ribosomal protein L18ae family Neighboring gene Winged helix-turn-helix transcription repressor DNA-binding protein Neighboring gene winged-helix DNA-binding transcription factor family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    4. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001036109.1
    NM_104300.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    part_of pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Dihydrolipoamide acetyltransferase, long form protein
    NP_001031186.1
    • Dihydrolipoamide acetyltransferase, long form protein; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity, acyltransferase activity; INVOLVED IN: pyruvate metabolic process, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT3G13930.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_564654.1
    • Dihydrolipoamide acetyltransferase, long form protein; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity, acyltransferase activity; INVOLVED IN: pyruvate metabolic process, metabolic process, acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide acetyltransferase, long form (InterPro:IPR006257), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide acetyltransferase, long form protein (TAIR:AT3G13930.1); Has 21519 Blast hits to 19723 proteins in 2310 species: Archae - 104; Bacteria - 12081; Metazoa - 737; Fungi - 478; Plants - 377; Viruses - 0; Other Eukaryotes - 7742 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20246026..20250345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104300.4 → NP_564654.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5M729, Q8L787, Q94IP5, Q9SLL0
      UniProtKB/TrEMBL
      A0A178W5Y1, A0A5S9WPJ8, A0A7G2E0R9
      Conserved Domains (1) summary
      PLN02744
      Location:2 → 539
      PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

    2. NM_001036109.1 → NP_001031186.1  Dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5M729, Q8L787, Q94IP5, Q9SLL0
      UniProtKB/TrEMBL
      A0A178W5Y1, A0A5S9WPJ8, A0A7G2E0R9
      Conserved Domains (1) summary
      PLN02744
      Location:2 → 539
      PLN02744; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M729.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools