NDPK2 nucleoside diphosphate kinase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NDPK2
Official Full Name: nucleoside diphosphate kinase 2
Primary source: TAIR:AT5G63310
Locus tag: AT5G63310
See related: Araport:AT5G63310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS NUCLEOSIDE DIPHOSPHATE KINASE 2; ATNDPK2; MDC12.28; MDC12_28; NDP KINASE 1A; NDPK IA; NDPK IA IA; NDPK1A; nucleoside diphosphate kinase 2; NUCLEOSIDE DIPHOSPHATE KINASE IA
Summary: Maintains intracellular dNTP levels except ATP. Plays a role in response to oxidative stress and UV. Involved in phytochrome-mediated light signaling. Participates in auxin-regulated processes, partly through the modulation of auxin transport. H-bonding with His-197 inside the nucleotide-binding pocket is critical for NDPK2 functioning.
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Genomic context

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See NDPK2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (25371904..25373904, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that enhanced AtNDPK2 expression affects oxidative stress tolerance leading to improved plant growth in transgenic poplar.
Title: Transgenic poplar expressing Arabidopsis NDPK2 enhances growth as well as oxidative stress tolerance.
Results suggest that nucleoside diphosphate kinase 2 acts as a GTPase-activating protein for small G proteins in plants.
Title: Arabidopsis nucleoside diphosphate kinase-2 as a plant GTPase activating protein.
NDPK2 plays a critical role in the AtPP7 regulation of the phytochrome pathway
Title: The protein phosphatase 7 regulates phytochrome signaling in Arabidopsis.
Data suggest that the interaction of SOS2 with both NDPK2 and CATs2 and 3 reveals a point of cross talk between salt stress response and other signaling factors including H2O2.
Title: Interaction of SOS2 with nucleoside diphosphate kinase 2 and catalases reveals a point of connection between salt stress and H2O2 signaling in Arabidopsis thaliana.
localizes only to chloroplasts, not to the cytosol
Title: Localisation of Arabidopsis NDPK2--revisited.
characterization of the interaction between phytochrome and NDPK2
Title: NDPK2 as a signal transducer in the phytochrome-mediated light signaling.
Data suggest that binding of nucleotide to nucleoside diphosphate kinase 2 (NDPK2) plays a regulatory role in phytochrome signaling and that the C-terminal extension of NDPK2 provides a potential binding surface for interaction with phytochromes.
Title: Structural analysis of Arabidopsis thaliana nucleoside diphosphate kinase-2 for phytochrome-mediated light signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125726.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within red, far-red light phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plastid	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: nucleoside diphosphate kinase 2

NP_568970.2

nucleoside diphosphate kinase 2 (NDPK2); FUNCTIONS IN: nucleoside diphosphate kinase activity, protein binding, ATP binding; INVOLVED IN: response to UV, auxin mediated signaling pathway, response to hydrogen peroxide, red, far-red light phototransduction; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleoside diphosphate kinase, core (InterPro:IPR001564); BEST Arabidopsis thaliana protein match is: Nucleoside diphosphate kinase family protein (TAIR:AT4G09320.1); Has 9088 Blast hits to 8922 proteins in 2598 species: Archae - 291; Bacteria - 4641; Metazoa - 1094; Fungi - 170; Plants - 375; Viruses - 117; Other Eukaryotes - 2400 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

25371904..25373904 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125726.4 → NP_568970.2 nucleoside diphosphate kinase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568970.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O64903, O65212, Q9SMX6

UniProtKB/TrEMBL

A0A178UPE3, A0A384KNJ7, A5Y7B8, Q0WUG9

Conserved Domains (1) summary

cd04413
Location:84 → 213

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...