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    ATMYC1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827965, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATMYC1
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT4G00480
    Locus tag
    AT4G00480
    See related
    Araport:AT4G00480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6N23.22; F6N23_22; myc1
    Summary
    MYC-related protein with a basic helix-loop-helix motif at the C-terminus and a region similar to the maize B/R family at the N-terminus
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    Genomic context

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    See ATMYC1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (216812..219926, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II transcription mediator Neighboring gene RHO guanyl-nucleotide exchange factor 3 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene beta-amylase 2 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Acyl-CoA thioesterase family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis. Urao T, et al. Plant Mol Biol, 1996 Nov. PMID 8980509
    2. The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana. Song H, et al. Plant J, 2023 Apr. PMID 36721966
    3. Natural allelic variation defines a role for ATMYC1: trichome cell fate determination. Symonds VV, et al. PLoS Genet, 2011 Jun. PMID 21695236, Free PMC Article
    4. Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis. Pesch M, et al. Development, 2013 Aug. PMID 23900543
    5. A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Zhao H, et al. J Biol Chem, 2012 Apr 20. PMID 22334670, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
      Title: The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
    2. AtMYC1 protein is predominantly localised in the cytoplasm and can relocate GL1 from the nucleus into the cytoplasm.
      Title: Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.
    3. AtMYC1 is an important regulator of trichome and root hair initiation
      Title: A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.
    4. Natural allelic variation defines a role for ATMYC1: trichome cell fate determination
      Title: Natural allelic variation defines a role for ATMYC1: trichome cell fate determination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001340255.1
    NM_116272.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in root hair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_001154194.1
    • ATMYC1; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G63650.3); Has 1481 Blast hits to 1090 proteins in 120 species: Archae - 0; Bacteria - 0; Metazoa - 3; Fungi - 0; Plants - 1462; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).
    NP_191957.2
    • ATMYC1; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G63650.3); Has 1473 Blast hits to 1082 proteins in 120 species: Archae - 0; Bacteria - 0; Metazoa - 3; Fungi - 0; Plants - 1458; Viruses - 0; Other Eukaryotes - 12 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      216812..219926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160722.2 → NP_001154194.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FKM9, F4JHC4, F8UGN9, F8UGP2, F8UGQ1
      Conserved Domains (2) summary
      smart00353
      Location:346 → 388
      HLH; helix loop helix domain
      pfam14215
      Location:23 → 216
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

    2. NM_116272.4 → NP_191957.2  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191957.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65257, P93651, Q8W2F1
      UniProtKB/TrEMBL
      A0A654FKM9, C0SVG1, F8UGN9, F8UGP2, F8UGQ1
      Conserved Domains (2) summary
      smart00353
      Location:346 → 388
      HLH; helix loop helix domain
      pfam14215
      Location:23 → 216
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

    3. NM_001340255.1 → NP_001329692.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8H4, A0A654FKM9, F8UGN9, F8UGP2, F8UGQ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W2F1.1

    Gene LinkOut

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