PIN3 Auxin efflux carrier family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PIN3
Official Full Name: Auxin efflux carrier family protein
Primary source: TAIR:AT1G70940
Locus tag: AT1G70940
See related: Araport:AT1G70940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS PIN-FORMED 3; ATPIN3; F15H11.14; F15H11_14; PIN-FORMED 3
Summary: A regulator of auxin efflux and involved in differential growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane and to vesicles. In roots, PIN3 is expressed without pronounced polarity in tiers two and three of the columella cells, at the basal side of vascular cells, and to the lateral side of pericycle cells of the elongation zone. PIN3 overexpression inhibits root cell growth. Protein phosphorylation plays a role in regulating PIN3 trafficking to the plasma membrane.
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Genomic context

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See PIN3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (26742940..26746469)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
Title: AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Title: Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Clathrin light chains regulate hypocotyl elongation by affecting the polarization of the auxin transporter PIN3 in Arabidopsis.
Title: Clathrin light chains regulate hypocotyl elongation by affecting the polarization of the auxin transporter PIN3 in Arabidopsis.
Osmotic stress represses root growth by modulating the transcriptional regulation of PIN-FORMED3.
Title: Osmotic stress represses root growth by modulating the transcriptional regulation of PIN-FORMED3.
PIN3 role in shoot branching.
Title: Cytokinin Targets Auxin Transport to Promote Shoot Branching.
activating a steroid-inducible variant of the auxin response factor (ARF) MONOPTEROS (MP) is sufficient to restore patterning and PIN gene expression.
Title: The auxin response factor MONOPTEROS controls meristem function and organogenesis in both the shoot and root through the direct regulation of PIN genes.
Two mechanistically distinct PIN3 polarization events redirect auxin fluxes at different time points of the gravity response: first, gravity-mediated redirection of PIN3-mediated auxin flow toward the lower hypocotyl side, where auxin gradually accumulates and promotes growth, and later PIN3 polarization to the opposite cell side, depleting this auxin maximum to end the bending.
Title: Termination of Shoot Gravitropic Responses by Auxin Feedback on PIN3 Polarity.
ABA treatment reduced the expression levels of the PIN-FORMEDs (PIN) auxin efflux carriers, PIN1, PIN3, PIN4, and PIN7, to a greater extent in the root meristems of arf2-101 mutant than in the wild type. ARF2 positively mediates the transcripts of transcription factor PLETHORA 1 (PLT1) gene but negatively mediates PLT2 at protein level in root meristems.
Title: ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.
Title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism.
ARF7 and FLP transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation.
Title: A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_105762.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables auxin efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in auxin export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auxin export across the plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to alkaline pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gravitropism	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of root meristem growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tropism	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Auxin efflux carrier family protein

NP_177250.1

PIN-FORMED 3 (PIN3); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: in 8 processes; LOCATED IN: lateral plasma membrane, plasma membrane, vesicle membrane, cell surface; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G23080.1); Has 1983 Blast hits to 1757 proteins in 550 species: Archae - 37; Bacteria - 1198; Metazoa - 14; Fungi - 0; Plants - 487; Viruses - 0; Other Eukaryotes - 247 (source: NCBI BLink).