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    PCK1 phosphoenolpyruvate carboxykinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829943, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PCK1
    Official Full Name
    phosphoenolpyruvate carboxykinase 1
    Primary source
    TAIR:AT4G37870
    Locus tag
    AT4G37870
    See related
    Araport:AT4G37870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PEPCK; PHOSPHOENOLPYRUVATE CARBOXYKINASE; phosphoenolpyruvate carboxykinase 1; T28I19.150; T28I19_150
    Summary
    Encodes a phosphoenolpyruvate carboxykinase that localizes to the cytosol.
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    Genomic context

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    See PCK1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (17802690..17806705, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene SPT2 chromatin protein Neighboring gene LisH/CRA/RING-U-box domains-containing protein Neighboring gene ncRNA Neighboring gene Zinc finger (C3HC4-type RING finger) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and manipulation of phosphoenolpyruvate carboxykinase 1 identifies a role for malate metabolism in stomatal closure. Penfield S, et al. Plant J, 2012 Feb. PMID 22007864
    2. C acid decarboxylases required for C photosynthesis are active in the mid-vein of the C species Arabidopsis thaliana, and are important in sugar and amino acid metabolism. Brown NJ, et al. Plant J, 2010 Jan. PMID 19807880
    3. Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment. Eastmond PJ, et al. Nat Commun, 2015 Apr 10. PMID 25858700, Free PMC Article
    4. BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis. Chen ZH, et al. Biochem J, 2007 Jul 1. PMID 17376028, Free PMC Article
    5. Proteomics of the response of Arabidopsis thaliana to infection with Alternaria brassicicola. Mukherjee AK, et al. J Proteomics, 2010 Feb 10. PMID 19857612

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment, one is via PCK1, and a second via PPDK.
      Title: Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment.
    2. Malate metabolism is important during dark-induced stomatal closure and that phosphoenolpyruvate carboxykinase (PEPCK) is involved in this process.
      Title: Expression and manipulation of phosphoenolpyruvate carboxykinase 1 identifies a role for malate metabolism in stomatal closure.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119948.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoenolpyruvate carboxykinase (ATP) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleolus HDA PubMed 

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase 1
    NP_195500.1
    • phosphoenolpyruvate carboxykinase 1 (PCK1); FUNCTIONS IN: phosphoenolpyruvate carboxykinase activity, purine nucleotide binding, phosphoenolpyruvate carboxykinase (ATP) activity, ATP binding; INVOLVED IN: defense response to fungus, incompatible interaction, response to cadmium ion, cellular response to phosphate starvation, gluconeogenesis; LOCATED IN: cytosol, nucleolus, nucleus, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoenolpyruvate carboxykinase, N-terminal (InterPro:IPR008210), Phosphoenolpyruvate carboxykinase (ATP), conserved site (InterPro:IPR015994), Phosphoenolpyruvate carboxykinase, ATP-utilising (InterPro:IPR001272), Phosphoenolpyruvate carboxykinase, C-terminal (InterPro:IPR013035); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxykinase 2 (TAIR:AT5G65690.1); Has 4504 Blast hits to 4501 proteins in 1411 species: Archae - 21; Bacteria - 2559; Metazoa - 2; Fungi - 139; Plants - 194; Viruses - 0; Other Eukaryotes - 1589 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17802690..17806705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119948.4 → NP_195500.1  phosphoenolpyruvate carboxykinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9T074
      UniProtKB/TrEMBL
      A0A178V3Z2, A0A654FWY7, Q0WWL8
      Conserved Domains (1) summary
      PLN02597
      Location:105 → 671
      PLN02597; phosphoenolpyruvate carboxykinase [ATP]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9T074.1

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