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    SEP4 K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814898, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEP4
    Official Full Name
    K-box region and MADS-box transcription factor family protein
    Primary source
    TAIR:AT2G03710
    Locus tag
    AT2G03710
    See related
    Araport:AT2G03710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 3; AGL3; F19B11.16; F19B11_16; MADS BOX PROTEIN; SEPALLATA 4
    Summary
    This gene belongs to the family of SEP genes. It is involved in the development of sepals, petals, stamens and carpels. Additionally, it plays a central role in the determination of flower meristem and organ identity.
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    Genomic context

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    See SEP4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (1129229..1131838)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene coenzyme Q biosynthesis Coq4 family protein / ubiquinone biosynthesis Coq4 family protein Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SEP4 gene of Arabidopsis thaliana functions in floral organ and meristem identity. Ditta G, et al. Curr Biol, 2004 Nov 9. PMID 15530395
    2. The Arabidopsis MADS-box gene AGL3 is widely expressed and encodes a sequence-specific DNA-binding protein. Huang H, et al. Plant Mol Biol, 1995 Jun. PMID 7632923
    3. Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Jetha K, et al. Nucleic Acids Res, 2014. PMID 25183521, Free PMC Article
    4. Protein interaction mapping reveals widespread targeting of development-related host transcription factors by phytoplasma effectors. Correa Marrero M, et al. Plant J, 2024 Feb. PMID 37965720
    5. Phytoplasma effector SAP54 hijacks plant reproduction by degrading MADS-box proteins and promotes insect colonization in a RAD23-dependent manner. MacLean AM, et al. PLoS Biol, 2014 Apr. PMID 24714165, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126418.2
    NM_179599.2
    NM_201682.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within petal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sepal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stamen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_178466.1
    • SEPALLATA 4 (SEP4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G15800.1); Has 7361 Blast hits to 7360 proteins in 917 species: Archae - 0; Bacteria - 4; Metazoa - 643; Fungi - 310; Plants - 6307; Viruses - 0; Other Eukaryotes - 97 (source: NCBI BLink).
    NP_849930.1
    • SEPALLATA 4 (SEP4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G15800.1); Has 7369 Blast hits to 7368 proteins in 921 species: Archae - 0; Bacteria - 4; Metazoa - 645; Fungi - 306; Plants - 6326; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).
    NP_973411.1
    • SEPALLATA 4 (SEP4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT5G15800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1129229..1131838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179599.2 → NP_849930.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWU5, A0A7G2E801
      Conserved Domains (2) summary
      cd00265
      Location:2 → 77
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:85 → 173
      K-box; K-box region

    2. NM_201682.3 → NP_973411.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973411.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29383
      Conserved Domains (2) summary
      cd00265
      Location:2 → 77
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:92 → 171
      K-box; K-box region

    3. NM_126418.2 → NP_178466.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04729, P29383, Q41252, Q7XJL0, Q8VZR9
      UniProtKB/TrEMBL
      A0A178VVE1, A0A5S9WWX0, A0A7G2E9M1
      Conserved Domains (2) summary
      cd00265
      Location:2 → 77
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:85 → 173
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29383.2

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