ACS6 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACS6
Official Full Name: 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6
Primary source: TAIR:AT4G11280
Locus tag: AT4G11280
See related: Araport:AT4G11280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6; ATACS6; F8L21.70; F8L21_70
Summary: encodes a a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family
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Genomic context

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See ACS6 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (6863979..6866116)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that glutathione (GSH) induces ethylene (ET)biosynthesis by modulating Arabidopsis proteins 1-aminocyclopropane-1-carboxylate synthase (ACS) via WRKY33 and 1-aminocyclopropane-1-carboxylate oxidase (ACO).
Title: Glutathione Regulates 1-Aminocyclopropane-1-Carboxylate Synthase Transcription via WRKY33 and 1-Aminocyclopropane-1-Carboxylate Oxidase by Modulating Messenger RNA Stability to Induce Ethylene Synthesis during Stress.
ACS2 and ACS6 are the main isoforms involved in Cd-induced ethylene production.
Title: Cadmium-induced ethylene production and responses in Arabidopsis thaliana rely on ACS2 and ACS6 gene expression.
Two abscisic acid (ABA)-activated calcium-dependent protein kinases, CPK4 and CPK11, phosphorylate the C-terminus of ACS6 and increase the stability of ACS6 in ethylene biosynthesis.
Title: Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis.
direct binding of WRKY33 to the W-boxes in the promoters of ACS2 and ACS6 genes in vivo, suggesting that WRKY33 is directly involved in the activation of ACS2 and ACS6 expression downstream of MPK3/MPK6 cascade in response to pathogen invasion
Title: Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis.
Protein phosphatase 2A inhibition stabilizes ACS6 protein.
Title: Protein phosphatase 2A controls ethylene biosynthesis by differentially regulating the turnover of ACC synthase isoforms.
ACS2 and ACS6 are involved in Botrytis-induced ethylene production.
Title: Mitogen-activated protein kinase 3 and 6 regulate Botrytis cinerea-induced ethylene production in Arabidopsis.
This study demonstrated that unphosphorylated ACS6 protein is rapidly degraded by the 26S proteasome pathway; the impact of this system on ethylene biosynthesis is discussed.
Title: MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway.
Data showed that the expression of ACS6 is induced during hypoxia.
Title: Differential expression of genes encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis during hypoxia.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_117199.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1-aminocyclopropane-1-carboxylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-aminocyclopropane-1-carboxylate synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEP Inferred from Expression Pattern more info	PubMed
involved_in ethylene biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ethylene biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water deprivation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6

NP_192867.1

1-aminocyclopropane-1-carboxylic acid (acc) synthase 6 (ACS6); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: ACC synthase 1 (TAIR:AT3G61510.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

6863979..6866116

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117199.2 → NP_192867.1 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192867.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82719, Q9SAR0, Q9SUT3

UniProtKB/TrEMBL

A0A178UYW5, A0A5S9XR83, A0A7G2EX83

Conserved Domains (1) summary

PLN02450
Location:12 → 435

PLN02450; 1-aminocyclopropane-1-carboxylate synthase