U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    G6PD1 glucose-6-phosphate dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833559, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    G6PD1
    Official Full Name
    glucose-6-phosphate dehydrogenase 1
    Primary source
    TAIR:AT5G35790
    Locus tag
    AT5G35790
    See related
    Araport:AT5G35790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glucose-6-phosphate dehydrogenase 1; MWP19.3
    Summary
    Encodes a plastidic glucose-6-phosphate dehydrogenase that is sensitive to reduction by DTT and whose mRNA is more prevalent in developing organs but absent in the root.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See G6PD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (13956672..13959830, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Redox regulation of chloroplastic G6PDH activity by thioredoxin occurs through structural changes modifying substrate accessibility and cofactor binding. Née G, et al. Biochem J, 2014 Jan 1. PMID 24079807
    2. Overcompensation in response to herbivory in Arabidopsis thaliana: the role of glucose-6-phosphate dehydrogenase and the oxidative pentose-phosphate pathway. Siddappaji MH, et al. Genetics, 2013 Oct. PMID 23934891, Free PMC Article
    3. Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol. Meyer T, et al. Plant J, 2011 Jun. PMID 21309870
    4. Redox regulation of chloroplastic glucose-6-phosphate dehydrogenase: a new role for f-type thioredoxin. Née G, et al. FEBS Lett, 2009 Sep 3. PMID 19631646
    5. Genome-wide analysis of glucose-6-phosphate dehydrogenases in Arabidopsis. Wakao S, et al. Plant J, 2005 Jan. PMID 15634201

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout studies of Transfer-DNA (T-DNA) insertion lines and complementation studies of G6PDH1 verify its role in compensation. G6PDH1 is a key enzyme in the oxidative pentose-phosphate pathway that plays a central role in plant metabolism.
      Title: Overcompensation in response to herbivory in Arabidopsis thaliana: the role of glucose-6-phosphate dehydrogenase and the oxidative pentose-phosphate pathway.
    2. Another example of modifications to catalytic properties of a chloroplastic enzyme upon redox regulation, but by a mechanism unique to G6PDH.
      Title: Redox regulation of chloroplastic G6PDH activity by thioredoxin occurs through structural changes modifying substrate accessibility and cofactor binding.
    3. Thioredoxin m2 retains G6PD4 in the cytosol, and could mediate redox-relayed interaction with G6PD1.
      Title: Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol.
    4. Results describe the redox regulation of plastidial glucose-6-phosphate dehydrogenase and found that its oxidative activation is strictly dependent on plastidial thioredoxins, including thioredoxin f, that show differential efficiencies.
      Title: Redox regulation of chloroplastic glucose-6-phosphate dehydrogenase: a new role for f-type thioredoxin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_122970.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pentose-phosphate shunt, oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast stroma HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glucose-6-phosphate dehydrogenase 1
    NP_198428.1
    • glucose-6-phosphate dehydrogenase 1 (G6PD1); FUNCTIONS IN: glucose-6-phosphate dehydrogenase activity, protein binding; INVOLVED IN: pentose-phosphate shunt, oxidative branch, glucose metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-6-phosphate dehydrogenase, C-terminal (InterPro:IPR022675), Glucose-6-phosphate dehydrogenase, active site (InterPro:IPR019796), NAD(P)-binding domain (InterPro:IPR016040), Glucose-6-phosphate dehydrogenase (InterPro:IPR001282), Glucose-6-phosphate dehydrogenase, NAD-binding (InterPro:IPR022674); BEST Arabidopsis thaliana protein match is: glucose-6-phosphate dehydrogenase 2 (TAIR:AT5G13110.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13956672..13959830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122970.6 → NP_198428.1  glucose-6-phosphate dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65577, Q43727, Q9FFM5
      UniProtKB/TrEMBL
      A0A654G5D7
      Conserved Domains (1) summary
      PLN02640
      Location:1 → 575
      PLN02640; glucose-6-phosphate 1-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q43727.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools