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    EIF4A1 eukaryotic translation initiation factor 4A1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820605, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIF4A1
    Official Full Name
    eukaryotic translation initiation factor 4A1
    Primary source
    TAIR:AT3G13920
    Locus tag
    AT3G13920
    See related
    Araport:AT3G13920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    eukaryotic translation initiation factor 4A1; RH4; TIF4A1
    Summary
    eukaryotic translation initiation factor 4A-1
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    Genomic context

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    See EIF4A1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (4592248..4595080, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene EPIDERMAL PATTERNING FACTOR-like protein Neighboring gene ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein Neighboring gene hypothetical protein (DUF3511) Neighboring gene ncRNA Neighboring gene Dihydrolipoamide acetyltransferase, long form protein Neighboring gene DNA binding / DNA-directed RNA polymerase Neighboring gene ankyrin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequences for two cDNAs encoding Arabidopsis thaliana eukaryotic protein synthesis initiation factor 4A. Metz AM, et al. Gene, 1992 Oct 21. PMID 1398145
    2. The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis. Bush MS, et al. Plant J, 2015 Dec. PMID 26493293, Free PMC Article
    3. In vivo interaction between CDKA and eIF4A: a possible mechanism linking translation and cell proliferation. Hutchins AP, et al. FEBS Lett, 2004 Jan 2. PMID 14706832
    4. eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation. Bush MS, et al. Plant Physiol, 2016 Sep. PMID 27388680, Free PMC Article
    5. MRF Family Genes Are Involved in Translation Control, Especially under Energy-Deficient Conditions, and Their Expression and Functions Are Modulated by the TOR Signaling Pathway. Lee DH, et al. Plant Cell, 2017 Nov. PMID 29084871, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (eIF4A)eIF4A1 and eIF4A2 on a conserved threonine residue (threonine-164) within the RNA-binding motif.
      Title: eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.
    2. EIF4A function is essential for plant growth and development in Arabidopsis.
      Title: The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084679.1
    NM_001202956.1
    NM_001338092.1
    NM_001338093.1
    NM_112246.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4A1
    NP_001078148.1
    • eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: cytosol, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 49587 Blast hits to 48995 proteins in 3133 species: Archae - 779; Bacteria - 27305; Metazoa - 6121; Fungi - 4627; Plants - 2620; Viruses - 17; Other Eukaryotes - 8118 (source: NCBI BLink).
    NP_001189885.1
    • eukaryotic translation initiation factor 4A1 (EIF4A1); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.2).
    NP_001319547.1
    • eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: response to cadmium ion, translational initiation; LOCATED IN: cytosol, nucleolus, cell wall, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566469.1
    • eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: response to cadmium ion, translational initiation; LOCATED IN: cytosol, nucleolus, cell wall, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 49714 Blast hits to 49117 proteins in 3142 species: Archae - 779; Bacteria - 27442; Metazoa - 6117; Fungi - 4773; Plants - 2624; Viruses - 17; Other Eukaryotes - 7962 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4592248..4595080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112246.4 → NP_566469.1  eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41376, Q0WWD9, Q546P0, Q8LBZ6, Q8RXF3, Q94CM1
      UniProtKB/TrEMBL
      A0A178V707, A0A5S9XC50
      Conserved Domains (1) summary
      PTZ00424
      Location:26 → 412
      PTZ00424; helicase 45; Provisional

    2. NM_001338092.1 → NP_001319547.1  eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z2Q9, F4JEL4
      Conserved Domains (1) summary
      PTZ00424
      Location:26 → 393
      PTZ00424; helicase 45; Provisional

    3. NM_001338093.1 → NP_001327653.1  eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSZ7, C0Z2Q9

    4. NM_001084679.1 → NP_001078148.1  eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XC50, A8MRZ7
      Conserved Domains (3) summary
      PTZ00424
      Location:16 → 402
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:242 → 371
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:31 → 231
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    5. NM_001202956.1 → NP_001189885.1  eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XC50, F4JEL5
      Conserved Domains (3) summary
      PTZ00424
      Location:26 → 407
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:247 → 376
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:41 → 236
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41376.1

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