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    CKX2 cytokinin oxidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816469, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CKX2
    Official Full Name
    cytokinin oxidase 2
    Primary source
    TAIR:AT2G19500
    Locus tag
    AT2G19500
    See related
    Araport:AT2G19500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCKX2; cytokinin oxidase 2; CYTOKININ OXIDASE 2; F3P11.10; F3P11_10
    Summary
    It encodes a protein whose sequence is similar to cytokinin oxidase/dehydrogenase, which catalyzes the degradation of cytokinins.
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    Genomic context

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    See CKX2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (8444204..8447355, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene casein kinase I-like 5 Neighboring gene nucleosome assembly protein 1;2 Neighboring gene recA DNA recombination family protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LOB domain-containing protein 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integration of epigenetic and genetic controls of seed size by cytokinin in Arabidopsis. Li J, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003120, Free PMC Article
    2. Prehistory and history of Arabidopsis research. Meyerowitz EM. Plant Physiol, 2001 Jan. PMID 11154286, Free PMC Article
    3. Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity. Werner T, et al. Plant Cell, 2003 Nov. PMID 14555694, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKX2 expression is activated by the IKU transcription factor WRKY10 directly and promotes endosperm growth.
      Title: Integration of epigenetic and genetic controls of seed size by cytokinin in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_127508.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokinin dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables primary methylamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytokinin oxidase 2
    NP_565455.1
    • cytokinin oxidase 2 (CKX2); CONTAINS InterPro DOMAIN/s: Cytokinin dehydrogenase 1, FAD/cytokinin binding domain (InterPro:IPR015345), FAD-binding, type 2 (InterPro:IPR016166), Oxygen oxidoreductase covalent FAD-binding site (InterPro:IPR006093), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094); BEST Arabidopsis thaliana protein match is: cytokinin oxidase 4 (TAIR:AT4G29740.2); Has 7392 Blast hits to 7387 proteins in 1327 species: Archae - 192; Bacteria - 4401; Metazoa - 106; Fungi - 1482; Plants - 576; Viruses - 0; Other Eukaryotes - 635 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8444204..8447355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127508.2 → NP_565455.1  cytokinin oxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FUJ3, Q9ZUP1
      UniProtKB/TrEMBL
      A0A5S9WZF9
      Conserved Domains (3) summary
      PLN02441
      Location:1 → 501
      PLN02441; cytokinin dehydrogenase
      pfam01565
      Location:57 → 195
      FAD_binding_4; FAD binding domain
      pfam09265
      Location:227 → 501
      Cytokin-bind; Cytokinin dehydrogenase 1, FAD and cytokinin binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FUJ3.2

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