DYT1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DYT1
Official Full Name: basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source: TAIR:AT4G21330
Locus tag: AT4G21330
See related: Araport:AT4G21330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DYSFUNCTIONAL TAPETUM 1; T6K22.60; T6K22_60
Summary: Encodes a bHLH transcription factor strongly expressed in the tapetum from late anther stage 5 to early stage 6, and at a lower level in meiocytes. dyt1 mutant exhibits abnormal anther morphology beginning at anther stage 4. DYT1 acts downstream of SPL/NZZ and EMS1/EXS, and is required for normal expression of AMS, MS1 and other tapetum preferential genes.
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Genomic context

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See DYT1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (11349922..11350694)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analyses of functional conservation and divergence reveal requirement of bHLH010/089/091 for pollen development at elevated temperature in Arabidopsis.
Title: Analyses of functional conservation and divergence reveal requirement of bHLH010/089/091 for pollen development at elevated temperature in Arabidopsis.
Mice with the DYT1 dystonia mutation exhibit an enhanced response to mu receptor activation, dependent on selective receptor gene upregulation..
Title: Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia.
Early onset torsion dystonia (DYT1) patient fibroblasts with heterozygous DYT1 mutant alleles showed decreased herpes simplex virus 1 plaque formation as compared to controls.
Title: Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.
DYT1 dystonia is a network disorder, with crucial nodes in sensory-motor integration of posterior parietal structures.
Title: Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers.
The results of this study suggested that motor impairments in DYT1 KI animals only exhibit when the sensory stimuli are strongly altered during performance.
Title: Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia.
Data said that the normal spatio-temporal subcellular localization of DYT1 is important for DYT1 function and/or that the BIF domains from different bHLH members might be functionally distinct.
Title: Feedback Regulation of DYT1 by Interactions with Downstream bHLH Factors Promotes DYT1 Nuclear Localization and Anther Development.
Here the authors demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
Title: DYT1 dystonia increases risk taking in humans.
we show the behavioral and molecular consequences of stressing the endoplasmic reticulum in DYT1 mice by increasing the amount of misfolded proteins
Title: Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.
DYT1 forms complexes with bHLH010, bHLH089 and bHLH091 subsequently affecting the correct expression of many DYT1 target genes.
Title: The DYT1-interacting proteins bHLH010, bHLH089 and bHLH091 are redundantly required for Arabidopsis anther development and transcriptome.
DYT1 regulates the expression of AMS, MS188/MYB80, TEK and MS1 for pollen wall formation, primarily via TDF1.
Title: DYT1 directly regulates the expression of TDF1 for tapetum development and pollen wall formation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anther wall tapetum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: basic helix-loop-helix (bHLH) DNA-binding superfamily protein

NP_193864.1

DYSFUNCTIONAL TAPETUM 1 (DYT1); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: tapetal layer development, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: tapetum, floral meristem, anther primordium; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT2G16910.1); Has 1140 Blast hits to 1140 proteins in 78 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 1137; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

11349922..11350694

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118253.1 → NP_193864.1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193864.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7Y5V9, O81900

UniProtKB/TrEMBL

A0A178UXT0, A0A654FRK3

Conserved Domains (1) summary

cd00083
Location:26 → 82

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...