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    OMT1 O-methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835504, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OMT1
    Official Full Name
    O-methyltransferase 1
    Primary source
    TAIR:AT5G54160
    Locus tag
    AT5G54160
    See related
    Araport:AT5G54160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCOMT; ATOMT1; caffeate O-methyltransferase 1; COMT1; K18G13.3; K18G13_3; O-methyltransferase 1; O-METHYLTRANSFERASE 1; O-methyltransferase 3; OMT3
    Summary
    A caffeic acid/5-hydroxyferulic acid O-methyltransferase. Interacts with 14-4-3 proteins in yeast 2 hybrid assay. AtOMT1 (At5g54160) encodes a flavonol 3?-O-methyltransferase that is highly active towards quercetin and myricetin. The substrate specificity identifies the enzyme as flavonol 3?-methyltransferase which replaces the former annotation of the gene to encode a caffeic acid/5-hydroxyferulic acid O-methyltransferase
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    Genomic context

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    See OMT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (21981902..21984399)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sarcosine dehydrogenase-2C protein Neighboring gene uncharacterized protein Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3'-O-methyltransferase and characterization of the gene product. Muzac I, et al. Arch Biochem Biophys, 2000 Mar 15. PMID 10700397
    2. A new Arabidopsis thaliana mutant deficient in the expression of O-methyltransferase impacts lignins and sinapoyl esters. Goujon T, et al. Plant Mol Biol, 2003 Apr. PMID 12777055
    3. The three-dimensional structure of Arabidopsis thaliana O-methyltransferase predicted by homology-based modelling. Yang H, et al. J Mol Graph Model, 2004 Sep. PMID 15331056
    4. Insights into lignin primary structure and deconstruction from Arabidopsis thaliana COMT (caffeic acid O-methyl transferase) mutant Atomt1. Moinuddin SG, et al. Org Biomol Chem, 2010 Sep 7. PMID 20652169
    5. H(2)S aids osmotic stress resistance by S-sulfhydration of melatonin production-related enzymes in Arabidopsis thaliana. Wang Z, et al. Plant Cell Rep, 2022 Feb. PMID 34812898

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H2S aids osmotic stress resistance by S-sulfhydration of melatonin production-related enzymes in Arabidopsis thaliana.
      Title: H(2)S aids osmotic stress resistance by S-sulfhydration of melatonin production-related enzymes in Arabidopsis thaliana.
    2. lignin degradative analysis resulted in release of a 5-hydroxyconiferyl alcohol (5OHG)-5OHG-G trimer from the Atomt1 mutant
      Title: Insights into lignin primary structure and deconstruction from Arabidopsis thaliana COMT (caffeic acid O-methyl transferase) mutant Atomt1.
    3. Data report the determination of the 3-D structure of Arabidopsis thaliana O-methyltransferase, AtOMT1 as well as its dynamics when complexed with its substrate.
      Title: The three-dimensional structure of Arabidopsis thaliana O-methyltransferase predicted by homology-based modelling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124796.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetylserotonin O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables caffeate O-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables caffeate O-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables flavone 3'-O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavone 3'-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myricetin 3'-O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quercetin 3-O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within melatonin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect regulation of anthocyanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mannitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect seed oilbody biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    O-methyltransferase 1
    NP_200227.1
    • O-methyltransferase 1 (OMT1); FUNCTIONS IN: myricetin 3'-O-methyltransferase activity, quercetin 3-O-methyltransferase activity, caffeate O-methyltransferase activity; INVOLVED IN: lignin biosynthetic process, flavonol biosynthetic process; LOCATED IN: cytosol, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Plant methyltransferase dimerisation (InterPro:IPR012967), O-methyltransferase, family 2 (InterPro:IPR001077), O-methyltransferase, COMT, eukaryota (InterPro:IPR016461); BEST Arabidopsis thaliana protein match is: O-methyltransferase family protein (TAIR:AT1G77520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21981902..21984399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124796.4 → NP_200227.1  O-methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49964, Q42170, Q9FK25
      UniProtKB/TrEMBL
      A0A178URF5, A0A5S9YG62, A0A654GB27
      Conserved Domains (2) summary
      pfam00891
      Location:138 → 342
      Methyltransf_2; O-methyltransferase
      pfam08100
      Location:34 → 83
      dimerization; dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FK25.1

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