U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GSA1 glutamate-1-semialdehyde-2,1-aminomutase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836476, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GSA1
    Official Full Name
    glutamate-1-semialdehyde-2,1-aminomutase
    Primary source
    TAIR:AT5G63570
    Locus tag
    AT5G63570
    See related
    Araport:AT5G63570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''glutamate-1-semialdehyde-2; 1-aminomutase; 1-AMINOMUTASE; 1-aminomutase''; glutamate-1-semialdehyde-2; GLUTAMATE-1-SEMIALDEHYDE-2; GSA-AM; MBK5.3; MBK5_3
    Summary
    Encodes a protein with homology to glutamate-1-semialdehyde 2,1-aminomutase catalyzing the conversion of glutamate-1-semialdehyde (GSA) into 5-amino levulinate. The expression of this gene was demonstrated to be light-induced.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GSA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (25451800..25453845)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DEK domain-containing chromatin associated protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene flavonol synthase 2 Neighboring gene flavonol synthase 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana. Song Y, et al. Acta Crystallogr F Struct Biol Commun, 2016 Jun. PMID 27303897, Free PMC Article
    2. Light regulation of chlorophyll biosynthesis at the level of 5-aminolevulinate formation in Arabidopsis. Ilag LL, et al. Plant Cell, 1994 Feb. PMID 7908550, Free PMC Article
    3. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633
    4. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001345595.1
    NM_125752.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutamate-1-semialdehyde 2,1-aminomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-1-semialdehyde 2,1-aminomutase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate-1-semialdehyde-2,1-aminomutase
    NP_201162.1
    • ''glutamate-1-semialdehyde-2,1-aminomutase'' (GSA1); FUNCTIONS IN: glutamate-1-semialdehyde 2,1-aminomutase activity; INVOLVED IN: response to light stimulus, porphyrin biosynthetic process; LOCATED IN: apoplast, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase class-III (InterPro:IPR005814), Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase (InterPro:IPR004639), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: glutamate-1-semialdehyde 2,1-aminomutase 2 (TAIR:AT3G48730.1); Has 34880 Blast hits to 34874 proteins in 2819 species: Archae - 734; Bacteria - 23560; Metazoa - 547; Fungi - 812; Plants - 385; Viruses - 2; Other Eukaryotes - 8840 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25451800..25453845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125752.4 → NP_201162.1  glutamate-1-semialdehyde-2,1-aminomutase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42799
      UniProtKB/TrEMBL
      A0A178UF15, A0A5S9YHD5, A0A654GDN2
      Conserved Domains (1) summary
      PLN02482
      Location:1 → 474
      PLN02482; glutamate-1-semialdehyde 2,1-aminomutase

    2. NM_001345595.1 → NP_001332291.1  glutamate-1-semialdehyde-2,1-aminomutase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UF15, A0A1P8BGJ8, A0A5S9YHD5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42799.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.