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    LOX1 lipoxygenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841944, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOX1
    Official Full Name
    lipoxygenase 1
    Primary source
    TAIR:AT1G55020
    Locus tag
    AT1G55020
    See related
    Araport:AT1G55020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS LIPOXYGENASE 1; ATLOX1; LIPOXYGENASE; lipoxygenase 1
    Summary
    lipoxygenase, a defense gene conferring resistance Xanthomonas campestris
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    Genomic context

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    See LOX1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (20525654..20530468)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene plant defensin 1.5 Neighboring gene miscRNA Neighboring gene RNI-like superfamily protein Neighboring gene miscRNA Neighboring gene zinc finger (Ran-binding) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate. Melan MA, et al. Plant Physiol, 1993 Feb. PMID 7506426, Free PMC Article
    2. Root-derived oxylipins promote green peach aphid performance on Arabidopsis foliage. Nalam VJ, et al. Plant Cell, 2012 Apr. PMID 22474183, Free PMC Article
    3. Role of 9-lipoxygenase and α-dioxygenase oxylipin pathways as modulators of local and systemic defense. Vicente J, et al. Mol Plant, 2012 Jul. PMID 22199234
    4. Facilitation of Fusarium graminearum Infection by 9-Lipoxygenases in Arabidopsis and Wheat. Nalam VJ, et al. Mol Plant Microbe Interact, 2015 Oct. PMID 26075826
    5. Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. Vellosillo T, et al. Plant Cell, 2007 Mar. PMID 17369372, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant 9-lipoxygenases (9-LOXs) are engaged during infection to control the balance between salicylic acid (SA) and jasmonic acid (JA) signaling to facilitate infection.
      Title: Facilitation of Fusarium graminearum Infection by 9-Lipoxygenases in Arabidopsis and Wheat.
    2. LOX1 and alpha-DOX1 contribute to plant defense by modulating hormonal responses. [LOX1]
      Title: Role of 9-lipoxygenase and α-dioxygenase oxylipin pathways as modulators of local and systemic defense.
    3. AtLOX-1 and AtLOX-5 are 9S-lipoxygenases.
      Title: Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104376.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables linoleate 9S-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within membrane disassembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoxygenase 1
    NP_175900.1
    • lipoxygenase 1 (LOX1); CONTAINS InterPro DOMAIN/s: Lipoxygenase, iron binding site (InterPro:IPR020833), Lipoxygenase, C-terminal (InterPro:IPR013819), Lipoxygenase, LH2 (InterPro:IPR001024), Lipase/lipooxygenase, PLAT/LH2 (InterPro:IPR008976), Lipoxygenase, conserved site (InterPro:IPR020834), Lipoxygenase (InterPro:IPR000907), Lipoxygenase, plant (InterPro:IPR001246); BEST Arabidopsis thaliana protein match is: PLAT/LH2 domain-containing lipoxygenase family protein (TAIR:AT3G22400.1); Has 1484 Blast hits to 1444 proteins in 180 species: Archae - 0; Bacteria - 84; Metazoa - 533; Fungi - 49; Plants - 793; Viruses - 0; Other Eukaryotes - 25 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20525654..20530468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104376.3 → NP_175900.1  lipoxygenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175900.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06327, Q9FZ30
      UniProtKB/TrEMBL
      A0A178W151, A0A5S9WLZ0
      Conserved Domains (3) summary
      PLN02337
      Location:1 → 859
      PLN02337; lipoxygenase
      cd01751
      Location:19 → 162
      PLAT_LH2; PLAT/ LH2 domain of plant lipoxygenase related proteins. Lipoxygenases are nonheme, nonsulfur iron dioxygenases that act on lipid substrates containing one or more (Z,Z)-1,4-pentadiene moieties. In plants, the immediate products are involved in defense ...
      pfam00305
      Location:174 → 842
      Lipoxygenase; Lipoxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06327.1

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