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    KNAT4 homeobox protein knotted-1-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830973, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KNAT4
    Official Full Name
    homeobox protein knotted-1-like 4
    Primary source
    TAIR:AT5G11060
    Locus tag
    AT5G11060
    See related
    Araport:AT5G11060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    KNOTTED1-like homeobox gene 4; T5K6.50; T5K6_50
    Summary
    A member of Class II KN1-like homeodomain transcription factors (together with KNAT3 and KNAT5), with greatest homology to the maize knox1 homeobox protein. Expression regulated by light. Detected in all tissues examined, but most prominent in leaves and young siliques. Transient expression of GFP translational fusion protein suggests bipartite localization in nucleus and cytoplasm. KNAT4 promoter activity showed cell-type specific pattern along longitudinal root axis; GUS expression pattern started at the elongation zone, predominantly in the phloem and pericycle cells, extending to endodermis toward the base of the root.
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    Genomic context

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    See KNAT4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (3509833..3513741)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TRS120 Neighboring gene myb domain protein 64 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three knotted1-like homeobox genes in Arabidopsis. Serikawa KA, et al. Plant Mol Biol, 1996 Nov. PMID 8980519
    2. A map of KNAT gene expression in the Arabidopsis root. Truernit E, et al. Plant Mol Biol, 2006 Jan. PMID 16463096
    3. A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Hackbusch J, et al. Proc Natl Acad Sci U S A, 2005 Mar 29. PMID 15781858, Free PMC Article
    4. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article
    5. Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo. Majerská J, et al. Protoplasma, 2017 Jul. PMID 27853871

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121144.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein knotted-1-like 4
    NP_196667.2
    • KNOTTED1-like homeobox gene 4 (KNAT4); FUNCTIONS IN: transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to light stimulus; LOCATED IN: cytosol, nucleus, cytoplasm; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ELK (InterPro:IPR005539), KNOX1 (InterPro:IPR005540), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), KNOX2 (InterPro:IPR005541), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: KNOTTED1-like homeobox gene 3 (TAIR:AT5G25220.1); Has 5905 Blast hits to 5890 proteins in 326 species: Archae - 0; Bacteria - 0; Metazoa - 2030; Fungi - 312; Plants - 3367; Viruses - 0; Other Eukaryotes - 196 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3509833..3513741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121144.4 → NP_196667.2  homeobox protein knotted-1-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196667.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48001, Q8GXD4, Q9FY59
      UniProtKB/TrEMBL
      A0A178UC59, A0A7G2FBS4
      Conserved Domains (3) summary
      pfam03790
      Location:124 → 161
      KNOX1; KNOX1 domain
      pfam03791
      Location:182 → 231
      KNOX2; KNOX2 domain
      pfam05920
      Location:326 → 365
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48001.3

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