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    LHW transcription factor-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817265, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LHW
    Official Full Name
    transcription factor-like protein
    Primary source
    TAIR:AT2G27230
    Locus tag
    AT2G27230
    See related
    Araport:AT2G27230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12K2.19; F12K2_19; LONESOME HIGHWAY
    Summary
    Encodes a nuclear-localized transcriptional activator with weak sequence similarity to basic helix-loop-helix(bHLH)-domain proteins. It promotes the production of stele cells in root meristems and is required to establish and maintain the normal vascular cell number and pattern in primary and lateral roots.
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    Genomic context

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    See LHW in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (11650358..11654143)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BEL1-like homeodomain 5 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene aluminum activated malate transporter family protein Neighboring gene CLAVATA3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Auxin-associated initiation of vascular cell differentiation by LONESOME HIGHWAY. Ohashi-Ito K, et al. Development, 2013 Feb. PMID 23362345
    2. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes. Ohashi-Ito K, et al. New Phytol, 2024 May. PMID 38462819
    3. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions. Wendrich JR, et al. Science, 2020 Nov 13. PMID 32943451, Free PMC Article
    4. Evolution of vascular plants through redeployment of ancient developmental regulators. Lu KJ, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31874927, Free PMC Article
    5. An atypical bHLH transcription factor regulates early xylem development downstream of auxin. Ohashi-Ito K, et al. Plant Cell Physiol, 2013 Mar. PMID 23359424

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
      Title: LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
    2. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
      Title: Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
    3. Study revealed the evolutionary trajectory for the heterodimeric TMO5/LHW transcription factor complex, which is rate-limiting for vascular cell proliferation in Arabidopsis thaliana. Both regulators have origins predating vascular tissue emergence, and even terrestrialization. TMO5 evolved its modern function, including dimerization with LHW, at the origin of land plants.
      Title: Evolution of vascular plants through redeployment of ancient developmental regulators.
    4. LHW functions as a key regulator to initiate vascular cell differentiation in association with auxin regulation.
      Title: Auxin-associated initiation of vascular cell differentiation by LONESOME HIGHWAY.
    5. LHW is nuclear-localized and is expressed in the root meristems, where we hypothesize it acts independently of other known root-patterning genes to promote the production of stele cells. [Lonesome Highway] [LHW]
      Title: Regulation of the Arabidopsis root vascular initial population by LONESOME HIGHWAY.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 11650592-11650696 AT2G27230.uORF1
    NM_001036353.1
    NM_128281.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of root meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stele development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor-like protein
    NP_001031430.1
    • LONESOME HIGHWAY (LHW); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092); BEST Arabidopsis thaliana protein match is: Serine/threonine-protein kinase WNK (With No Lysine)-related (TAIR:AT1G64625.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_565640.1
    • LONESOME HIGHWAY (LHW); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092); BEST Arabidopsis thaliana protein match is: Serine/threonine-protein kinase WNK (With No Lysine)-related (TAIR:AT1G64625.3); Has 448 Blast hits to 377 proteins in 66 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 446; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11650358..11654143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128281.2 → NP_565640.1  transcription factor-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGI1, Q0WMN8, Q9XIN0
      UniProtKB/TrEMBL
      A0A178VXD3, A0A5S9X1X6, A0A7G2EC48
      Conserved Domains (2) summary
      cd18915
      Location:459 → 529
      bHLH_AtLHW_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein LONESOME HIGHWAY (LHW) and similar proteins
      pfam14215
      Location:5 → 159
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

    2. NM_001036353.1 → NP_001031430.1  transcription factor-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGI1, Q0WMN8, Q9XIN0
      UniProtKB/TrEMBL
      A0A178VXD3, A0A5S9X1X6, A0A7G2EC48
      Conserved Domains (2) summary
      cd18915
      Location:459 → 529
      bHLH_AtLHW_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein LONESOME HIGHWAY (LHW) and similar proteins
      pfam14215
      Location:5 → 159
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIN0.1

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