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    ROPGEF1 rho guanyl-nucleotide exchange factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830000, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROPGEF1
    Official Full Name
    rho guanyl-nucleotide exchange factor 1
    Primary source
    TAIR:AT4G38430
    Locus tag
    AT4G38430
    See related
    Araport:AT4G38430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATROPGEF1; F22I13.200; F22I13_200; KINASE PARTNER PROTEIN-LIKE; KPP-LIKE; rho guanyl-nucleotide exchange factor 1; ROP (rho of plants) guanine nucleotide exchange factor 1
    Summary
    Member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily, also known as DUF315). Interacts with ROP1 but the whole protein lacks Rho guanyl-nucleotide exchange factor activity in vitro. The DUF315/PRONE domain is sufficient to confer RopGEF catalytic activity.
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    Genomic context

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    See ROPGEF1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (17986384..17988869)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Dehydrin family protein Neighboring gene SKU5 similar 9 Neighboring gene RPAP1-like, carboxy-terminal protein Neighboring gene geranylgeranyl reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases. Li Z, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686103, Free PMC Article
    2. RopGEF1 Plays a Critical Role in Polar Auxin Transport in Early Development. Liu Y, et al. Plant Physiol, 2017 Sep. PMID 28698357, Free PMC Article
    3. FERONIA receptor-like kinase regulates RHO GTPase signaling of root hair development. Duan Q, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876100, Free PMC Article
    4. Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs. Li Z, et al. PLoS Biol, 2016 May. PMID 27192441, Free PMC Article
    5. ROPGEF1 and ROPGEF4 are functional regulators of ROP11 GTPase in ABA-mediated stomatal closure in Arabidopsis. Li Z, et al. FEBS Lett, 2012 May 7. PMID 22500990

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPK4 binds to and phosphorylates RopGEF1 and promotes the degradation of RopGEF1
      Title: Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases.
    2. critical for AUX1 localization and PIN differential accumulation; role in cell polarity and polar auxin transport whereby it impacts auxin-mediated plant growth and development
      Title: RopGEF1 Plays a Critical Role in Polar Auxin Transport in Early Development.
    3. PP2C protein phosphatases protect and stabilize RopGEF1 from abscisic acid -mediated degradation.RopGEF1 is epistatic to PP2C phosphatases in abscisic acid signal transduction pathway.RopGEF1 plays an important role in abscisic acid -mediated inhibition of lateral root growth.
      Title: Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs.
    4. ROPGEF1 and ROPGEF4 are specific regulators of ROP11 function in ABA-mediated stomatal closure
      Title: ROPGEF1 and ROPGEF4 are functional regulators of ROP11 GTPase in ABA-mediated stomatal closure in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120005.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanyl-nucleotide exchange factor 1
    NP_195556.1
    • rho guanyl-nucleotide exchange factor 1 (ROPGEF1); CONTAINS InterPro DOMAIN/s: Rop nucleotide exchanger, PRONE (InterPro:IPR005512); BEST Arabidopsis thaliana protein match is: RHO guanyl-nucleotide exchange factor 7 (TAIR:AT5G02010.1); Has 308 Blast hits to 304 proteins in 16 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 308; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17986384..17988869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120005.4 → NP_195556.1  rho guanyl-nucleotide exchange factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZY2, Q9SVE2
      UniProtKB/TrEMBL
      A0A178UUK9, A0A5S9Y025
      Conserved Domains (1) summary
      pfam03759
      Location:89 → 457
      PRONE; PRONE (Plant-specific Rop nucleotide exchanger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZY2.2

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